Sean T. Prigge

Johns Hopkins University

United States

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Articles (10)

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2022

Ferredoxin (Fd) and ferredoxin-NADP+ reductase (FNR) form one of the few known redox systems in the apicoplast of malaria parasites and provide reducing power to iron-sulfur (FeS) cluster proteins within the organelle. While the Fd/FNR system has been explored as a drug target, the essentiality and roles of this system and the identity of its downstream FeS proteins have not been determined.

Year:

2022

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Collaborators (3)

Paul Sigala

Assistant Professor

University of Utah School of Medicine

UNITED STATES

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Krithika Rajaram

Assistant Professor

Ohio State University

UNITED STATES

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Stephan M. Hacker

NETHERLANDS

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Sean T. Prigge

Research Interests

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Articles (10)

A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites

Eine chemisch‐proteomische Strategie identifiziert Inhibitoren der Lipoat‐Wiederverwertung in Bakterien und Parasiten

The Plasmodium falciparum apicoplast cysteine desulfurase provides sulfur for both iron-sulfur cluster assembly and tRNA modification

The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation

Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

Roles of Ferredoxin-Dependent Proteins in the Apicoplast of Plasmodium falciparum Parasites

The ferredoxin redox system – an essential electron distributing hub in the apicoplast of Apicomplexa

Metabolic changes accompanying the loss of fumarate hydratase and malate–quinone oxidoreductase in the asexual blood stage of Plasmodium falciparum

Inter-study and time-dependent variability of metabolite abundance in cultured red blood cells

Dephospho‐CoA kinase, a nuclear‐encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption

Collaborators (3)

Paul Sigala

Krithika Rajaram

Stephan M. Hacker

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