Sebastian Leptihn

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Health and Medical University

Germany

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About

Professor Sebastian Leptihn is a faculty member at the Health and Medical University in Germany. His research primarily focuses on bacteriophages and their application in combating bacterial infections, particularly in relation to Vibrio parahaemolyticus and Pseudomonas aeruginosa. Recent publications include studies on phage therapy mechanisms, antibiotic resistance, and genetic characterizations of various bacterial species.

Recent Grants

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Molecular, clinical and socio-epidemiological analyses of 2019 nCoV for the development of novel diagnostic and therapeutic tools

Open Date: 2020-02-01

Close Date:

Grant: Close

Fully Integrated Lab on Chip Systems for High-Efficiency Single Cell Analysis

Open Date: 2019-01-01

Close Date: 2020-01-01

Grant: Close

Understanding Infection and Development of Alternative Strategies to Combat Bacterial Pathogens

Open Date: 2018-10-01

Close Date: 2024-12-01

Grant: Close

Studying insertion, folding and assembly of ion channels at the single molecule level.

Open Date: 2015-01-01

Close Date:

Grant: Close

Energy generation by biological thermosynthesis

Open Date: 2014-07-23

Close Date: 2016-01-23

Articles (18)

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2025

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2023

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2022

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2022

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2022

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2022

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2022

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2022

Collaborators (1)

Dann Turner

Senior Lecturer in Molecular Biology

University of the West of England

UNITED KINGDOM

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Sebastian Leptihn

Research Interests

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Contact this professor

About

Recent Grants

Articles (18)

A novel vibriophage vB_Vp_PvVp04 against pathogenic Vibrio parahaemolyticus and its formulation for inclusion in shrimp feed

Complete genome sequence of Vibrio diabolicus bacteriophage vB_Vc_SrVc2 and its efficacy as prophylactic phage therapy

Characteristics and phylogenetic distribution of megaplasmids and prediction of a putative chromid in <i>Pseudomonas aeruginosa</i>.

Phage-antibiotic combinations to control Pseudomonas aeruginosa-Candida two-species biofilms.

<i>In vitro</i> and <i>in vivo</i> evaluation of the biofilm-degrading <i>Pseudomonas</i> phage Motto, as a candidate for phage therapy.

Defense and anti-defense mechanisms of bacteria and bacteriophages

Mutation in the two-component regulator BaeSR mediates cefiderocol resistance and enhances virulence in <i>Acinetobacter baumannii</i>.

Pdif-mediated antibiotic resistance genes transfer in bacteria identified by pdifFinder

An XDR Pseudomonas aeruginosa ST463 Strain with an IncP-2 Plasmid Containing a Novel Transposon Tn<i>6485f</i> Encoding <i>bla</i><sub>IMP-45</sub> and <i>bla</i><sub>AFM-1</sub> and a Second Plasmid with Two Copies of <i>bla</i><sub>KPC-2</sub>.

Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae

IS26 mediated blaCTX-M-65 amplification in Escherichia coli increase the antibiotic resistance to cephalosporin in vivo

Characterization of two novel VIM-type metallo-β-lactamases, VIM-84 and VIM-85, associated with the spread of IncP-2 megaplasmids in <i>Pseudomonas aeruginosa</i>.

Complete Genome Sequence of Pseudomonas Phage Motto

Structural Basis of PER-1-Mediated Cefiderocol Resistance and Synergistic Inhibition of PER-1 by Cefiderocol in Combination with Avibactam or Durlobactam in Acinetobacter baumannii.

A Lysozyme Murein Hydrolase with Broad-Spectrum Antibacterial Activity from Enterobacter Phage myPSH1140

Description of a Rare Pyomelanin-Producing Carbapenem-Resistant Acinetobacter baumannii Strain Coharboring Chromosomal OXA-23 and NDM-1

Phage Resistance Reduced the Pathogenicity of Xanthomonas oryzae pv. oryzae on Rice

Therapeutic Evaluation of the Acinetobacter baumannii Phage Phab24 for Clinical Use

Collaborators (1)

Dann Turner

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