Sergey Krupenko

Professor

University of North Carolina

United States

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Professor Sergey Krupenko is a faculty member at the University of North Carolina, United States. His research primarily focuses on metabolomics, specifically the roles of glycine and serine in metabolic pathways, as well as the impact of ALDH1L1 on various forms of cancer. Recent publications highlight his investigations into the metabolic effects of dietary folate and the mechanisms by which ALDH1L1 regulates tumor growth and development.

Articles (6)

Year:

2024

Year:

2022

Year:

2022

Year:

2021

Year:

2021

Year:

2021

Collaborators (4)

Michael Coleman

Assistant Professor

University of North Carolina at Chapel Hill

UNITED STATES

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Kyle Strickland

Assistant Professor

Duke Medicine

UNITED STATES

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Blake Rushing

Assistant Professor

University of North Carolina at Chapel Hill

UNITED STATES

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Kris Helke

Associate Professor

Medical University of South Carolina

UNITED STATES

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Sergey Krupenko

Research Interests

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Articles (6)

Untargeted Metabolomics Reveals Dysregulation of Glycine- and Serine-Coupled Metabolic Pathways in an ALDH1L1-Dependent Manner In Vivo

Exploratory Metabolomics Underscores the Folate Enzyme ALDH1L1 as a Regulator of Glycine and Methylation Reactions

Sex-Specific Metabolic Effects of Dietary Folate Withdrawal in Wild-Type and <i>Aldh1l1</i> Knockout Mice

Knockout of Putative Tumor Suppressor Aldh1l1 in Mice Reprograms Metabolism to Accelerate Growth of Tumors in a Diethylnitrosamine (DEN) Model of Liver Carcinogenesis.

Metabolic Response of Triple-Negative Breast Cancer to Folate Restriction

Is ALDH1L1 Elevated in Lung Cancer? Comment on: Lee, S.-H.; et al. “The Combination of Loss of ALDH1L1 Function and Phenformin Treatment Decreases Tumor Growth in KRAS-Driven Lung Cancer” <i>Cancers</i> 2020, <i>12</i>, 1382

Collaborators (4)

Michael Coleman

Kyle Strickland

Blake Rushing

Kris Helke

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