Sergio Marchini

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Head Humanitas Genomic Facility (HuGe)

IRCCS Humanitas Research Hospital

Italy

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About

Dr. Sergio Marchini is the Head of the Humanitas Genomic Facility (HuGe) at IRCCS Humanitas Research Hospital in Italy. His research focuses on immune evasion mechanisms in cancer, particularly in ovarian carcinoma, as evidenced by his recent articles that explore regulatory T cell dynamics and machine learning applications in oncology. Additionally, he investigates genetic factors and their impact on treatment responses, contributing to the field of personalized medicine through studies on HRD assessment and therapeutic strategies.

Recent Grants

Grant: Open

MINERVA: Multimodal IntegratioN data in EaRly stage epithelial oVArian cancer

Open Date: 2025-01-01

Close Date: 2029-12-01

Grant: Close

Janus-Seq:a pan-cancer tumor agnostic platform to implement the use of liquid biopsy in the clinical setting of malignant mesothelioma

Open Date: 2025-01-01

Close Date: 2025-01-01

Grant: Open

MDR-RADefining Clinical and Molecular Phenotypes of Multi-Drug Resistance in difficult to treat Rheumatoid Arthritis

Open Date: 2025-01-01

Close Date: 2030-01-01

Grant: Close

Early diagnosis of high-grade serous epithelial ovarian cancer through the analysis of DNA derived from Pap Test smear

Open Date: 2024-01-01

Close Date: 2026-01-01

Grant: Open

A phase IV trial testing Olaparib and Bevacizumab as frontline Treatment of HRD positive ovarian tumours - IOLANTHE

Open Date: 2024-01-01

Close Date: 2027-01-01

Articles (10)

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2025

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2025

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2025

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2025

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2025

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2025

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2025

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2024

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Humanitas University

ITALY

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Sergio Marchini

Research Interests

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About

Recent Grants

Articles (10)

Correction to: Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics (Cell Death & Disease, (2025), 16, 1, (229), 10.1038/s41419-025-07557-5)

Immune evasion mechanisms in early-stage I high-grade serous ovarian carcinoma: insights into regulatory T cell dynamics

Autoimmune-Like Mechanism in Heart Failure Enables Preventive Vaccine Therapy

Unraveling the complexity of HRD assessment in ovarian cancer by combining genomic and functional approaches: translational analyses of MITO16-MaNGO-OV-2 trial

HR-SC—an academic-developed machine learning framework to classify HRD-positive ovarian cancer patients and predict sensitivity to olaparib

SAMURAI: shallow analysis of copy number alterations using a reproducible and integrated bioinformatics pipeline

TP53 mutations and survival in ovarian carcinoma patients receiving first-line chemotherapy plus bevacizumab: Results of the MITO16A/MaNGO OV-2 study

C/EBPβ-dependent autophagy inhibition hinders NK cell function in cancer

Harmonization of homologous recombination deficiency testing in ovarian cancer: Results from the MITO16A/MaNGO-OV2 trial

In-Silico Identification of Novel Pharmacological Synergisms: The Trabectedin Case

Collaborators (8)

Domenico Mavilio

Paolo Kunderfranco

Giulia Marelli

Antonino Musolino

Fabio Grizzi

Marinos Kallikourdis

Maurizio D'Incalci

Gianluigi Condorelli

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