Shahram Kordasti
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United KingdomResearch Interests
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Recent Grants
Grant: Close
Immunogenesis of the myelodysplasia of the stem and progenitor cells
Open Date: 2015-09-01
Close Date: 2018-08-01
Grant: Close
Comparison of the immune signature in haemolytic paroxysmal nocturnal haemoglobinuria (PNH) with aplastic anaemia (AA)/PNH and the effect of immunosuppression or C5 blockade on the frequency of CD1d restricted T- cells
Open Date: 2015-07-01
Close Date: 2018-07-01
Grant: Close
Immune dysregulation and genetics of Bone Marrow Failure Syndromes
Open Date: 2015-01-01
Close Date: 2018-12-01
Grant: Close
Immune dysregulation in bone marrow failure syndromes: implications for pathogenesis and clonal evolution
Open Date: 2011-01-01
Close Date: 2014-01-01
Articles (11)
Summary The unexpected higher level of IFNγ in a subset of patients with acute myeloid leukemia (AML; IFNγhigh) upregulates immunosuppressive genes in mesenchymal stem cells (MSC) and expands regulatory T cells through IDO1 overexpression. IDO1 and IFNG gene expression was positively correlated and required both leukemia cells and MSCs, as IFNγhigh cells were not able to induce Tregs alone. See related article by Corradi et al., p. 3141
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Collaborators (5)
Kilian Wistuba-Hamprecht
University Hospital Tübingen
Marco Romano
King’s College London
Niloufar Safinia
Clinical Senior Lecturer, honorary consultant transplant hepatologist
King’s College London
Voon Ong
University College London
Kevin Blighe
University College London
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