Shauna L. Parkes

Adaptive behaviour often necessitates that animals learn about events in a manner that is specific to a particular context or environment. These hierarchical organisations allow the animal to decide which action is the most appropriate when faced with ambiguous or conflicting possibilities. This study examined the role of hippocampus in enabling animals to use the context to guide action selection. We used a hierarchical instrumental outcome devaluation task in which male rats learn that the context provides information about the unique action‐outcome relations that are in effect. We first confirmed that rats encode and use hierarchical context‐(action‐outcome) relations. We then show that chemogenetic inhibition of ventral hippocampus impairs both the encoding and retrieval of these associations, while inhibition of dorsal hippocampus impairs only the retrieval. Importantly, neither dorsal nor ventral hippocampus was required for goal‐directed behaviour per se as these impairments only emerged when rats were forced to use the context to identify the current action‐outcome relationships. These findings are discussed with respect to the role of the hippocampus and its broader circuitry in the contextual modulation of goal‐directed behaviour and the importance of hierarchical associations in flexible behaviour.

Since the 1950s study of Scoville and Milner on the case H.M., the hippocampus has attracted neuroscientists’ attention. The hippocampus has been traditionally divided into dorsal and ventral parts, each of which projects to different brain structures and mediates various functions. Despite a predominant interest in its dorsal part in animal models, especially regarding episodic-like and spatial cognition, recent data highlight the role of the ventral hippocampus (vHPC), as the main hippocampal output, in cognitive processes. Here, we review recent studies conducted in rodents that have used advanced in vivo functional techniques to specifically monitor and manipulate vHPC efferent pathways and delineate the roles of these specific projections in learning and memory processes. Results highlight that vHPC projections to basal amygdala are implicated in emotional memory, to nucleus accumbens in social memory and instrumental actions and to prefrontal cortex in all the above as well as in object-based memory. Some of these hippocampal projections also modulate feeding and anxiety-like behaviours providing further evidence that the “one pathway-one function” view is outdated and future directions are proposed to better understand the role of hippocampal pathways and shed further light on its connectivity and function.