Sheila S. David

University of California

United States

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Articles (12)

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2024

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2024

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2023

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2023

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2022

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2021

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2020

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2020

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2020

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2020

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2020

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2020

Collaborators (5)

Jonathan Ashby

Assistant Professor

Mount Holyoke College

UNITED STATES

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Mariarosaria De Rosa

University of Pittsburgh

UNITED STATES

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Robert Van Ostrand

Ph.D. Candidate / Head Teaching Assistant / Chemical Safety Officer

University of California, Davis

UNITED STATES

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Martin Horvath

Associate Professor

University of Utah

UNITED STATES

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Sylvie Doublie

Professor

University of Vermont

UNITED STATES

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Sheila S. David

Research Interests

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Articles (12)

Cellular Repair of Synthetic Analogs of Oxidative DNA Damage Reveals a Key Structure–Activity Relationship of the Cancer-Associated MUTYH DNA Repair Glycosylase

FSHing for DNA Damage: Key Features of MutY Detection of 8-Oxoguanine:Adenine Mismatches

Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism

Structural and biochemical insights into NEIL2’s preference for abasic sites

NEIL1 Recoding due to RNA Editing Impacts Lesion-Specific Recognition and Excision

RNA Editing of the Human DNA Glycosylase NEIL1 Alters Its Removal of 5-Hydroxyuracil Lesions in DNA

Unique Hydrogen Bonding of Adenine with the Oxidatively Damaged Base 8-Oxoguanine Enables Specific Recognition and Repair by DNA Glycosylase MutY

Designer Fluorescent Adenines Enable Real-Time Monitoring of MUTYH Activity

Detection of OG:A Lesion Mispairs by MutY Relies on a Single His Residue and the 2-Amino Group of 8-Oxoguanine

2′-Fluorinated Hydantoins as Chemical Biology Tools for Base Excision Repair Glycosylases

The DNA repair enzyme MUTYH potentiates cytotoxicity of the alkylating agent MNNG by interacting with abasic sites

Structural Basis for Finding OG Lesions and Avoiding Undamaged G by the DNA Glycosylase MutY

Collaborators (5)

Jonathan Ashby

Mariarosaria De Rosa

Robert Van Ostrand

Martin Horvath

Sylvie Doublie

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