Shengyi Sun

Associate professor

University of Virginia

United States

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Shengyi Sun is an Associate Professor at the University of Virginia, USA. His research primarily focuses on endoplasmic reticulum-associated degradation (ERAD), examining mechanisms related to protein misfolding and homeostasis, particularly in mammalian systems. Recent publications highlight the role of SEL1L-HRD1 in various biological processes, including spermatogenesis, iron homeostasis, and kidney function.

Articles (12)

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2025

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2025

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2024

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2023

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2023

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2022

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2022

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2021

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2021

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2021

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Baylor College of Medicine

UNITED STATES

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Shengyi Sun

Research Interests

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Articles (12)

SEL1L–HRD1-mediated ERAD in mammals

The ER-associated degradation adaptor SEL1L is dispensable for ER homeostasis and the differentiation of spermatogenic cells

Proteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis

The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes

Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin

The mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand

Cellular abundance of sodium phosphate cotransporter SLC20A1/PiT1 and phosphate uptake are controlled post-transcriptionally by ESCRT

Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β-selection.

Protein Aggregation in the ER: Calm behind the Storm

Endoplasmic reticulum–associated degradation is required for nephrin maturation and kidney glomerular filtration function

Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions.

ER associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity.

Collaborators (5)

Daisuke Nakada

Andre Catic

Shuangcheng Wu

Ling Qi

Xi Chen

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