Shih-Hsing Leir

Assistant Professor

Case Western Reserve University

United States

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Shih-Hsing Leir is an Assistant Professor at Case Western Reserve University, located in the United States. His research focuses on cystic fibrosis, examining cellular responses in lung and pancreas models, as well as the functional genomics of the human epididymis. Recent publications include studies on cellular imbalances in cystic fibrosis sheep models and the regulation of CFTR expression during endoderm differentiation.

Articles (12)

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2025

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2024

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2023

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2023

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2022

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2022

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2021

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2021

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2021

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2021

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2021

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2020

Collaborators (2)

Ann Harris

UNITED STATES

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Arnaud J. Van Wettere

Utah State University

UNITED STATES

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Shih-Hsing Leir

Research Interests

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Articles (12)

Cellular imbalance in proximal and distal lung of CFTR−/− sheep in utero and at birth

Stellate cells are in utero markers of pancreatic disease in cystic fibrosis

Functional genomics of the human epididymis: Further characterization of efferent ducts and model systems by single‐cell RNA sequencing analysis

Early developmental phenotypes in the cystic fibrosis sheep model

Enhancement of airway epithelial cell differentiation by pulmonary endothelial cell co-culture.

Cell function and identity revealed by comparative scRNA-seq analysis in human nasal, bronchial and epididymis epithelia.

BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression

Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics.

Krüppel-like factor 5 regulates wound repair and the innate immune response in human airway epithelial cells

OTX2 regulates CFTR expression during endoderm differentiation and occupies 3′ cis‐regulatory elements

The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells

An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR

Collaborators (2)

Ann Harris

Arnaud J. Van Wettere

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