Shina Caroline Lynn Kamerlin

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Professor and Georgia Research Alliance Eminent Scholar

Georgia Institute of Technology

United States

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About

Shina Caroline Lynn Kamerlin is a Professor and Georgia Research Alliance Eminent Scholar at the Georgia Institute of Technology in the United States. Her research areas include generative AI techniques in protein engineering, computational design of enzymes, and the evolutionary dynamics of proteins. Recent publications highlight her work on enzyme enhancement, protein function and evolutionary adaptation, as well as academic challenges faced by students in relation to immigration policies.

Recent Grants

Grant: Close

Wallenberg Scholar

Open Date: 2020-07-01

Close Date: 2024-06-01

Grant: Close

Ligand-kontrollerad konformationsförändring som drivkraft för evolutionen av enzymer

Open Date: 2020-01-01

Close Date: 2023-12-31

Grant: Close

Wallenberg Academy Fellowship Prolongation

Open Date: 2019-07-01

Close Date: 2024-06-01

Grant: Close

Generating and understanding de novo enzyme functionalities using ancestral proteins as scaffolds

Open Date: 2017-05-01

Close Date: 2020-04-30

Grant: Close

The physics of genetic information processing

Open Date: 2017-01-01

Close Date: 2022-12-31

Articles (30)

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Collaborators (7)

M. Angeles Jimenez

SPAIN

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Joanna Slusky

Assistant Professor

University of Kansas

UNITED STATES

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Rafael Guimaraes da Silva

University of St. Andrews

UNITED KINGDOM

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Facundo Fernandez

Vasser-Wooley Professor

Georgia Institute of Technology

UNITED STATES

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Robert Kourist

Univ.-Prof. at Graz University of Technology

Graz University of Technology

AUSTRIA

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Alvan Hengge

Professor

Utah State University

UNITED STATES

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Reinhard Sterner

GERMANY

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Shina Caroline Lynn Kamerlin

Research Interests

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About

Recent Grants

Articles (30)

Enzyme Enhancement Through Computational Stability Design Targeting NMR-Determined Catalytic Hotspots

Generative AI techniques for conformational diversity and evolutionary adaptation of proteins

Complete computational design of high-efficiency Kemp elimination enzymes

Students must not be collateral damage in immigration clampdowns

Redefining the Limits of Functional Continuity in the Early Evolution of P-Loop NTPases

NIH’s 15% cap: a cost comparison and research outlook

Using AI to prepare for academic interviews – don’t trade authenticity for polish

Targeting MarA N‐terminal domain dynamics to prevent DNA binding

Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching Lactonases

Conformational Modulation of a Mobile Loop Controls Catalysis in the (βα)8-Barrel Enzyme of Histidine Biosynthesis HisF

SHP-1 Variants Broaden the Understanding of pH-Dependent Activities in Protein Tyrosine Phosphatases

Mandatory national language requirements in higher education

In vitro fertilization and the ethics of frozen embryos

Key interaction networks: Identifying evolutionarily conserved non‐covalent interaction networks across protein families

The ineligibility barrier for international researchers in US academia

Friends and relatives: insight into conformational regulation from orthologues and evolutionary lineages using KIF and KIN

Sequence – dynamics – function relationships in protein tyrosine phosphatases

Using residue interaction networks to understand protein function and evolution and to engineer new proteins

The winter holidays are glorious—except when they’re not

KIF—Key Interactions Finder: A program to identify the key molecular interactions that regulate protein conformational changes

Representation matters: responding to the current campaign against DEI efforts

Publisher Correction: Loop dynamics and the evolution of enzyme activity

Science after Brexit: bright spots on the Horizon?

Loop dynamics and the evolution of enzyme activity

Conformational Selection of a Tryptophan Side Chain Drives the Generalized Increase in Activity of PET Hydrolases through a Ser/Ile Double Mutation

The perceived decline of “disruptive” science and technology

How to write a successful graduate school application

Allosteric rescue of catalytically impaired ATP phosphoribosyltransferase variants links protein dynamics to active-site electrostatic preorganisation

Scholars in peril: when being a scientist can land you in jail (or worse)

A Structural View into the Complexity of Carbon Dioxide Fixation

Collaborators (7)

M. Angeles Jimenez

Joanna Slusky

Rafael Guimaraes da Silva

Facundo Fernandez

Robert Kourist

Alvan Hengge

Reinhard Sterner

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