Shishir Chundawat

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Associate Professor

Rutgers University

United States

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Shishir Chundawat is an Associate Professor at Rutgers The State University of New Jersey, USA. His research focuses on carbohydrate biosynthesis and its implications for monoclonal antibody production, with recent articles exploring topics such as glycosylation homogeneity and cellulose biosynthesis in plant systems. He investigates the engineering of carbohydrate-binding modules and their applications in biomanufacturing, contributing to advancements in therapeutic N-glycan preparation techniques.

Recent Grants

Grant: Close

Automated N-linked glycan analysis PAT to enable continuous biologics manufacturing

Open Date: 2020-07-01

Close Date: 2020-12-01

Grant: Close

Collaborative Research: Mechanism-guided enzyme engineering for fucosylated glycoconjugate synthesis

Open Date: 2019-08-01

Close Date: 2022-07-31

Grant: Close

CAREER: Force spectroscopy enabled multivalent glycan-binding protein engineering

Open Date: 2019-06-01

Close Date: 2024-05-31

Grant: Close

Advanced continuous upstream manufacturing of biotherapeutics

Open Date: 2018-09-20

Close Date: 2021-08-31

Grant: Close

Computationally Designed Cellulases to Decrease the Cost of Biofuels

Open Date: 2018-09-01

Close Date: 2021-12-01

Articles (16)

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UNITED STATES

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Shishir Chundawat

Research Interests

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Recent Grants

Articles (16)

Time-resolved tracking of cellulose biosynthesis and assembly during cell wall regeneration in live Arabidopsis protoplasts

Temporal Galactose‐Manganese Feeding in Fed‐Batch and Perfusion Bioreactors Modulates UDP‐Galactose Pools for Enhanced mAb Glycosylation Homogeneity

Evaluating the impact of media and feed combinations on CHO cell culture performance and monoclonal antibody (trastuzumab) production

Supercharging Carbohydrate Binding Module Alone Enhances Endocellulase Thermostability, Binding, and Activity on Cellulosic Biomass

Thermobifida fusca Cel6B moves bidirectionally while processively degrading cellulose

Engineering and characterization of carbohydrate‐binding modules for imaging cellulose fibrils biosynthesis in plant protoplasts

Plant cellulose synthase membrane protein isolation directly from Pichia pastoris protoplasts, liposome reconstitution, and its enzymatic characterization

Recent Advances in Biologic Therapeutic N-Glycan Preparation Techniques and Analytical Methods for Facilitating Biomanufacturing Automation

Automated instant labeling chemistry workflow for real-time monitoring of monoclonal antibody N-glycosylation

Oriented display of cello-oligosaccharides for pull-down binding assays to distinguish binding preferences of glycan binding proteins

Recent advances in integrated process analytical techniques, modeling, and control strategies to enable continuous biomanufacturing of monoclonal antibodies

Integrated Process Analytical Platform for Automated Monitoring of Monoclonal Antibody N-Linked Glycosylation

Click-Chemistry-Based Free Azide versus Azido Sugar Detection Enables Rapid In Vivo Screening of Glycosynthase Activity

Engineered Regulon to Enable Autonomous Azide Ion Biosensing, Recombinant Protein Production, and in Vivo Glycoengineering

Reduced type‐A carbohydrate‐binding module interactions to cellulose I leads to improved endocellulase activity

Molecular origins of reduced activity and binding commitment of processive cellulases and associated carbohydrate-binding proteins to cellulose III

Collaborators (5)

Heather Mayes

Eric Lam

Mohammad Irfan

Sang-Hyuk Lee

Ou Yang

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