Silvio Tosatto
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About
Silvio Tosatto is a Full Professor at Università degli Studi di Padova, Italy. His research areas encompass multi-omics characterization, mathematical modeling of tumor-induced angiogenesis, and protein structure analysis, with a particular focus on intrinsically disordered proteins and tandem repeat proteins. Recent articles include significant contributions to the understanding of integrin isoforms and advancements in computational tools for predicting protein properties.
Recent Grants
Grant: Close
Driving the functional characterization of intrinsically disordered proteins
Open Date: 2018-03-01
Close Date: 2022-11-30
Positions (1)
University of Padova
University of Padova
3 months ago
BioComputingUP at the University of Padova is preparing an upcoming PhD opportunity focused on the development, maintenance, and evolution of the DisProt platform, a widely used biological database and resource for the scientific community. The position sits at the intersection of bioinformatics , software engineering , biomedical research , and biocuration . The selected candidate will work on new features for the DisProt web platform, improve user experience, integrate biological resources, and develop AI-assisted tools for literature curation, annotation, and data analysis. The role also includes backend services, frontend improvements, database architecture, testing, documentation, and deployment. The lab is led by Prof. Silvio Tosatto and is part of an international research environment that develops resources such as DisProt and MobiDB and participates in ELIXIR and European projects. This is a strong fit for candidates interested in scientific software, biological databases, web development, APIs, data visualization, and AI-assisted annotation tools. Eligibility highlights: a Master’s degree in Computer Science, Bioinformatics, Computational Biology, Software Engineering, or a related field; strong Python skills; and interest in scientific software and biological databases. Experience with JavaScript, REST APIs, Git, Linux, and web development is beneficial. AI/LLM familiarity is optional but welcomed. Application window: the official doctoral call is expected to open shortly, and applications are accepted until 2026-07-21 . Interested candidates should prepare a CV, a concise research/personal statement, and reference details, then follow the application instructions on the job opening page.
3 months ago
Articles (24)
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2025
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2025
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2025
Cryptochromes are cardinal constituents of the circadian clock, which orchestrates daily physiological rhythms in living organisms. A growing body of evidence points to their participation in pathways that have not traditionally been associated with circadian clock regulation, implying that cryptochromes may be subject to modulation by multiple signaling mechanisms. In this study, we demonstrate that human CRY2 (hCRY2) forms a complex with the large, modular scaffolding protein known as Multi‐PDZ Domain Protein 1 (MUPP1). This interaction is facilitated by the calcium‐binding protein Calmodulin (CaM) in a calcium‐dependent manner. Our findings suggest a novel cooperative mechanism for the regulation of mammalian cryptochromes, mediated by calcium ions (Ca 2+ ) and CaM. We propose that this Ca 2+ /CaM‐mediated signaling pathway may be an evolutionarily conserved mechanism that has been maintained from Drosophila to mammals, most likely in relation to its potential role in the broader context of cryptochrome function and regulation. Further, the understanding of cryptochrome interactions with other proteins and signaling pathways could lead to a better definition of its role within the intricate network of molecular interactions that govern circadian rhythms.
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2024
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2024
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2023
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2023
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2023
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2022
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2022
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2022
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2022
Collaborators (11)
Michele Vendruscolo
Professor
University of Cambridge
Damiano Piovesan
Assistant professor
University of Padua
Gabriella M. Mazzotta
-
Tatsuhiko Tsunoda
Professor
University of Tokyo
Monika Fuxreiter
University of Padova
Giulio Tesei
Associate Senior Lecturer
Malmö University
Md Tamjidul Hoque
University of New Orleans
Zsuzsanna Dosztányi
Eötvös Loránd University
Isabelle Callebaut
Sorbonne Université
Giovanni Minervini
Assistant Professor
University of Padova
Alexander Monzon
Assistant Professor Tenure-Track (RTT researcher)
University of Padua
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