Silvio Tosatto

Has grant

Prof.

University of Padova
Country flagItaly

Research Interests

Explore related searches

Contact this professor

Get a free first email built on one of their papers, ready for you to edit and send yourself.

About

Silvio Tosatto is a Full Professor at Università degli Studi di Padova, Italy. His research areas encompass multi-omics characterization, mathematical modeling of tumor-induced angiogenesis, and protein structure analysis, with a particular focus on intrinsically disordered proteins and tandem repeat proteins. Recent articles include significant contributions to the understanding of integrin isoforms and advancements in computational tools for predicting protein properties.

Recent Grants

Grant: Close

Driving the functional characterization of intrinsically disordered proteins

Open Date: 2018-03-01

Close Date: 2022-11-30

Positions (1)

Publisher
source

University of Padova

University of Padova

BioComputingUP at the University of Padova is preparing an upcoming PhD opportunity focused on the development, maintenance, and evolution of the DisProt platform, a widely used biological database and resource for the scientific community. The position sits at the intersection of bioinformatics , software engineering , biomedical research , and biocuration . The selected candidate will work on new features for the DisProt web platform, improve user experience, integrate biological resources, and develop AI-assisted tools for literature curation, annotation, and data analysis. The role also includes backend services, frontend improvements, database architecture, testing, documentation, and deployment. The lab is led by Prof. Silvio Tosatto and is part of an international research environment that develops resources such as DisProt and MobiDB and participates in ELIXIR and European projects. This is a strong fit for candidates interested in scientific software, biological databases, web development, APIs, data visualization, and AI-assisted annotation tools. Eligibility highlights: a Master’s degree in Computer Science, Bioinformatics, Computational Biology, Software Engineering, or a related field; strong Python skills; and interest in scientific software and biological databases. Experience with JavaScript, REST APIs, Git, Linux, and web development is beneficial. AI/LLM familiarity is optional but welcomed. Application window: the official doctoral call is expected to open shortly, and applications are accepted until 2026-07-21 . Interested candidates should prepare a CV, a concise research/personal statement, and reference details, then follow the application instructions on the job opening page.

3 months ago

Articles (24)

Year:

2025

Year:

2025

Year:

2025

Year:

2025

Year:

2025

Year:

2025

Cryptochromes are cardinal constituents of the circadian clock, which orchestrates daily physiological rhythms in living organisms. A growing body of evidence points to their participation in pathways that have not traditionally been associated with circadian clock regulation, implying that cryptochromes may be subject to modulation by multiple signaling mechanisms. In this study, we demonstrate that human CRY2 (hCRY2) forms a complex with the large, modular scaffolding protein known as Multi‐PDZ Domain Protein 1 (MUPP1). This interaction is facilitated by the calcium‐binding protein Calmodulin (CaM) in a calcium‐dependent manner. Our findings suggest a novel cooperative mechanism for the regulation of mammalian cryptochromes, mediated by calcium ions (Ca 2+ ) and CaM. We propose that this Ca 2+ /CaM‐mediated signaling pathway may be an evolutionarily conserved mechanism that has been maintained from Drosophila to mammals, most likely in relation to its potential role in the broader context of cryptochrome function and regulation. Further, the understanding of cryptochrome interactions with other proteins and signaling pathways could lead to a better definition of its role within the intricate network of molecular interactions that govern circadian rhythms.

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Collaborators (11)

Michele Vendruscolo

Professor

University of Cambridge

UNITED KINGDOM
View details

Damiano Piovesan

Assistant professor

University of Padua

ITALY
View details

Gabriella M. Mazzotta

-

ITALY
View details

Tatsuhiko Tsunoda

Professor

University of Tokyo

JAPAN
View details

Monika Fuxreiter

University of Padova

ITALY
View details

Giulio Tesei

Associate Senior Lecturer

Malmö University

SWEDEN
View details

Md Tamjidul Hoque

University of New Orleans

UNITED STATES
View details

Zsuzsanna Dosztányi

Eötvös Loránd University

HUNGARY
View details

Isabelle Callebaut

Sorbonne Université

FRANCE
View details

Giovanni Minervini

Assistant Professor

University of Padova

ITALY
View details

Alexander Monzon

Assistant Professor Tenure-Track (RTT researcher)

University of Padua

ITALY
View details
ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts before you send them.