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Simak Ali

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Imperial College London

United Kingdom

Research Interests

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Professors in United Kingdom Professors in Cell Biology Cell Biology professors in United Kingdom

Recent Grants

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Development of potent clinical candidate CDK7 inhibitors for treatment of prostate cancer

Open Date: 2021-12-01

Close Date: 2024-11-30

Grant: Close

Modelling Estrogen Receptor Fusion Genes that Drive Endocrine Resistance in Metastatic Breast Cancer to Determine Function and Develop Therapeutic Str

Open Date: 2021-03-15

Close Date: 2024-08-30

Grant: Close

Developing strategies for treatment of breast cancer patients following progression on CDK4/6 inhibitors

Open Date: 2018-06-04

Close Date: 2021-06-03

Grant: Close

Mi-CARE: A Microchip-based diagnostic Companion for Early Detection and Therapeutic Monitoring of Breast Cancer

Open Date: 2018-01-01

Close Date: 2020-12-31

Grant: Close

Modeling estrogen receptor mutations in metastatic breast cancer – developing new insights into endocrine resistance and approaches for therapy

Open Date: 2015-03-09

Close Date: 2018-03-08

Articles (20)

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Collaborators (21)

Jean-Philippe Theurillat

Associate Professor

Università del Salento

SWITZERLAND

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Muralidharan Anbalagan

Assistant Professor

Tulane University

UNITED STATES

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Jacqui Shaw

Head of Department

University of Leicester

UNITED KINGDOM

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Gareth J. Thomas

University of Southampton

UNITED KINGDOM

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Raoul Charles Coombes

Professor of Medical Oncology

Imperial College London

UNITED KINGDOM

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Alyssa Nicholls

University of Cambridge

UNITED KINGDOM

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Christopher Hanley

University of Southampton

UNITED KINGDOM

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Charlotte Lynne Bevan

Imperial College London

UNITED KINGDOM

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Emmanuel Acheampong

Lecturer

University of Leicester

UNITED KINGDOM

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University of Southampton

UNITED KINGDOM

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Athina Giannoudis

Lecturer in Biomedical Science

University of Liverpool

UNITED KINGDOM

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Zahi I Mitri

Oregon Health & Science University

UNITED STATES

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Senior Lecturer and Principal Investigator

RCSI University of Medicine and Health Sciences

IRELAND

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Simak Ali

Research Interests

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Recent Grants

Articles (20)

Author Correction: Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells

Band-stop microfluidics for high-purity, label-free enrichment of viable cancer cells from whole blood

Correction: Abstract 3768 Role of Liver kinase B1 and its downstream kinases as regulators of estrogen receptor signaling in ER+ breast cancer

Sakuranetin modulates estrogen receptor signaling in breast cancer cells

Distinct 2-phenylimidazo[1,2-a]pyridine derivatives that inhibit breast cancer cell proliferation identified as AHR ligands

Resistance to CDK7 inhibitors directed by acquired mutation of a conserved residue in cancer cells

Author Correction: Dose escalation and expansion cohorts in patients with advanced breast cancer in a Phase I study of the CDK7-inhibitor samuraciclib

TRIM24 as a therapeutic target in endocrine treatment-resistant breast cancer

Modulation of estrogen receptor activity by the phytoalexin tuberosin produced from elicited kudzu Pueraria lobata

Overexpression of midasin drives cancer stem cell dynamics in <i>ESR1</i> mutant breast cancer

Targeting the Her2 and ERα receptors has a significant impact on therapy-resistant ER-positive breast cancer

Screening of a kinase inhibitor library identified novel targetable kinase pathways in triple-negative breast cancer

Analysis of Breast Cancer Brain Metastases Reveals an Enrichment of Cyclin-Dependent Kinase 12 Structural Rearrangements in Human Epidermal Growth Factor Receptor 2–Positive Disease

Serial Postoperative Circulating Tumor DNA Assessment Has Strong Prognostic Value During Long-Term Follow-Up in Patients With Breast Cancer

Induction of the TEAD Coactivator VGLL1 by Estrogen Receptor–Targeted Therapy Drives Resistance in Breast Cancer

Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma

Interrogating Estrogen Signaling Pathways in Human ER-Positive Breast Cancer Cells Forming Bone Metastases in Mice

Correction: low dose iron treatments induce a DNA damage response in human endothelial cells within minutes

Erratum: Serial postoperative circulating tumor DNA assessment has strong prognostic value during long-term follow-up in patients with breast cancer

PO2-24-04: Exploring the role and therapeutic potential of Ubiquitin Specific Peptidase 11 (USP11) in estrogen receptor positive breast cancer

Collaborators (21)

Jean-Philippe Theurillat

Muralidharan Anbalagan

Jacqui Shaw

Gareth J. Thomas

Raoul Charles Coombes

Alyssa Nicholls

Christopher Hanley

Charlotte Lynne Bevan

Emmanuel Acheampong

Ali Salehi-Reyhani

Richard Baird

Carlo Palmieri

Ian Reddin

Athina Giannoudis

Zahi I Mitri

Ian Tracy

Sima Ehsani

Laki Buluwela

Tim Fenton

Basil Greber

Damir Vareslija

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