Sjoerd Wanrooij

associate Professor

Umeå Universitet Medicinska fakulteten

Sweden

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Dr. Sjoerd Wanrooij is an Associate Professor at Umeå universitet Medicinska fakulteten in Sweden. His research primarily focuses on mitochondrial DNA dynamics, G-quadruplex structures, and their implications in oncogenic processes. Recent publications emphasize the mechanisms of DNA synthesis, mitochondrial stability, and potential therapeutic strategies involving G4-ligands and antibiotics in cancer models.

Articles (16)

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2025

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2025

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2024

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2024

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2023

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2021

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2021

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2021

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2021

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2020

Collaborators (11)

Juan Mendez

Lab Head

Centro Nacional de Investigaciones Oncológicas

SPAIN

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Kenji Ichiyanagi

Nagoya University

JAPAN

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Hiroyuki Sasaki

Kyushu University

JAPAN

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Kazutoshi Kasho

Kyushu University

JAPAN

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Ikenna Obi

Umea University

SWEDEN

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Jaakko L. O. Pohjoismäki

FINLAND

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Jan Jamroskovic

Umea University

SWEDEN

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Erik Chorell

Umea University

SWEDEN

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Fan-Yan Wei

Professor

Tohoku University

JAPAN

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Ludmilla A. Morozova-Roche

rProfesso

Umeå Universitet Medicinska fakulteten

SWEDEN

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Takashi Ishiuchi

Associate Professor

University of Yamanashi

JAPAN

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Sjoerd Wanrooij

Research Interests

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Articles (16)

The POLγ Y951N patient mutation disrupts the switch between DNA synthesis and proofreading, triggering mitochondrial DNA instability

TEFM facilitates transition from RNA synthesis to DNA synthesis at H-strand replication origin of mtDNA

Linker Design Principles for the Precision Targeting of Oncogenic G-Quadruplex DNA with G4-Ligand-Conjugated Oligonucleotides

Activating AMPK improves pathological phenotypes due to mtDNA depletion.

Exploring the Dispersion and Electrostatic Components in Arene–Arene Interactions between Ligands and G4 DNA to Develop G4-Ligands

MRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses.

G4-Ligand-Conjugated Oligonucleotides Mediate Selective Binding and Stabilization of Individual G4 DNA Structures.

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells.

Unravelling the Therapeutic Potential of Antibiotics in Hypoxia in a Breast Cancer MCF-7 Cell Line Model.

Rolling Circle Replication and Bypass of Damaged Nucleotides.

A complementary chemical probe approach towards customized studies of G-quadruplex DNA structures in live cells

TFB2M and POLRMT are essential for mammalian mitochondrial DNA replication.

Motif WFYY of human PrimPol is crucial to stabilize the incoming 3'-nucleotide during replication fork restart.

Human Polymerase δ-Interacting Protein 2 (PolDIP2) Inhibits the Formation of Human Tau Oligomers and Fibrils.

A unique arginine cluster in PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol.

Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization.

Collaborators (11)

Juan Mendez

Kenji Ichiyanagi

Hiroyuki Sasaki

Kazutoshi Kasho

Ikenna Obi

Jaakko L. O. Pohjoismäki

Jan Jamroskovic

Erik Chorell

Fan-Yan Wei

Ludmilla A. Morozova-Roche

Takashi Ishiuchi

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