Sophie de Seigneux
University of Geneva
SwitzerlandResearch Interests
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Articles (1)
Phosphoenolpyruvate carboxykinase 1 (PCK1) is highly expressed in the proximal tubule. We show here that this enzyme is crucial for the maintenance of normal tubular physiology, lactate, and glucose homeostasis. PCK1 is a regulator of acid-base balance and ammoniagenesis. Preventing PCK1 downregulation during renal injury improves renal function, rendering it an important target during renal disease.
Year:
2023
Collaborators (1)
Carsten A Wagner
University of Zurich
SWITZERLAND
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