Sriram Neelamegham

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Asst. - Full Professor

University at Buffalo - North Campus

United States

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About

Dr. Sriram Neelamegham is an Assistant Professor at the University at Buffalo - North Campus in the United States. His research focuses on protein engineering, particularly in the design of lectins and glycosyltransferases, as well as their applications in mRNA delivery and photodynamic therapy. Recent work includes advancements in understanding glycosylation pathways through single-cell transcriptomics and the role of glycosylation in viral infectivity.

Recent Grants

Grant: Close

Systems Biology of Glycosylation

Open Date: 2011-09-05

Close Date: 2016-06-30

Grant: Close

Von Willebrand Factor structure and function under fluid flow

Open Date: 2004-07-01

Close Date: 2016-11-30

Grant: Close

FLUID FORCES REGULATING PROTEIN STRUCTURE AND FUNCTION

Open Date: 2004-04-15

Close Date: 2009-03-31

Grant: Close

Selectin mediated cell adhesion under hydrodynamic shear

Open Date: 2001-04-01

Close Date: 2016-03-31

Articles (14)

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2025

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2020

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2020

Collaborators (7)

Julian Ugonotti

Macquarie University

AUSTRALIA

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John M. Canty

University at Buffalo

UNITED STATES

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Morten Thaysen-Andersen

Macquarie University

AUSTRALIA

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Sayantani Chatterjee

Macquarie University

AUSTRALIA

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Qi Yang

Beth Israel Deaconess Medical Center

UNITED STATES

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Harry Tjondro

Macquarie University

AUSTRALIA

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Alexander Diehl

Associate Professor

University at Buffalo

UNITED STATES

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Sriram Neelamegham

Research Interests

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About

Recent Grants

Articles (14)

Tuning the tropism and infectivity of SARS-CoV-2 virus-like particles for mRNA delivery

Protein engineering strategies to develop lectins by design

Engineering glycosyltransferases into glycan binding proteins using a mammalian surface display platform

Mammalian Cell Surface Display for High‐Throughput Protein Engineering of Glycosyltransferases

Cell- and tissue-specific glycosylation pathways informed by single-cell transcriptomics

Photosensitizer-thioglycosides enhance photodynamic therapy by augmenting cellular uptake

N-acetyl-β-D-hexosaminidases mediate the generation of paucimannosidic proteins via a putative noncanonical truncation pathway in human neutrophils

GlycoEnzOnto: a GlycoEnzyme pathway and molecular function ontology

Role for N -glycans and calnexin-calreticulin chaperones in SARS-CoV-2 Spike maturation and viral infectivity

Forward Genetic Screens of Human Glycosylation Pathways Using the GlycoGene CRISPR Library

Neutrophils aid cellular therapeutics by enhancing glycoengineered stem cell recruitment and retention at sites of inflammation

A systems-based framework to computationally describe putative transcription factors and signaling pathways regulating glycan biosynthesis

Inhibition of SARS-CoV-2 viral entry upon blocking N- and O-glycan elaboration

Robustness in glycosylation systems: effect of modified monosaccharides, acceptor decoys and azido sugars on cellular nucleotide-sugar levels and pattern of N-linked glycosylation

Collaborators (7)

Julian Ugonotti

John M. Canty

Morten Thaysen-Andersen

Sayantani Chatterjee

Qi Yang

Harry Tjondro

Alexander Diehl

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