Stefano Gianni

Full Professor

Università degli Studi di Roma La Sapienza

Italy

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About

Stefano Gianni is a Full Professor at Università degli Studi di Roma La Sapienza, Italy. His research primarily focuses on protein folding mechanisms, ligand binding free energy estimation, and protein-protein interactions. Recent publications include investigations into the folding pathways of SH2 domains and the binding properties of intrinsically disordered proteins. He explores the application of these findings in the context of treating viral infections, neurodegeneration, and cancer.

Articles (13)

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2025

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2025

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2024

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2024

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2023

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2022

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2022

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2022

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2021

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2021

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2021

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2021

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2020

Collaborators (6)

Uppsala University

SWEDEN

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Stefano Gianni

Research Interests

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Contact this professor

About

Articles (13)

A single buried cysteine acts as a hydrophobic stabilizer of a folding intermediate and transition state in the MATH domain of SPOP

Estimation of Ligand Binding Free Energy Using Multi-eGO

The Mechanism of Folding of Human Frataxin in Comparison to the Yeast Homologue – Broad Energy Barriers and the General Properties of the Transition State

Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD

An intramolecular energetic network regulates ligand recognition in a SH2 domain

Cryptic binding properties of a transient folding intermediate in a PDZ tandem repeat

Characterization of early and late transition states of the folding pathway of a SH2 domain

Unveiling induced folding of intrinsically disordered proteins – Protein engineering, frustration and emerging themes

Determining folding and binding properties of the C‐terminal SH2 domain of SHP2

Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer

Folding and Misfolding of a PDZ Tandem Repeat

Fuzziness and Frustration in the Energy Landscape of Protein Folding, Function, and Assembly

Comparing the binding properties of peptides mimicking the Envelope protein of SARS‐CoV and SARS‐CoV‐2 to the PDZ domain of the tight junction‐associated PALS1 protein

Collaborators (6)

Angelo Toto

serena rinaldo

Per Jemth

Lucia Marcocci

Carlo Camilloni

Ylva Ivarsson

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