Stephen Fink
Associate Professor
United StatesResearch Interests
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About
Stephen Fink is an Associate Professor at Case Western Reserve University in the United States. His research areas include hyaluronan degradation, enzymatic resolution, and the functionalization of sulfinyl esters. He has contributed to the field through recent articles focusing on small molecule inhibitors of 15-PGDH and their role in promoting tissue repair and regeneration.
Articles (4)
Year:
2024
α‐Sulfinyl esters can be readily prepared through thiol substitution of α‐bromo esters followed by oxidation to the sulfoxide. Enzymatic resolution with lipoprotein lipase provides both the unreacted esters and corresponding α‐sulfinyl carboxylic acids in high yields and enantiomeric ratios. Subsequent decarboxylative halogenation, dihalogenation, trihalogenation and cross‐coupling gives rise to functionalized sulfoxides. The method has been applied to the asymmetric synthesis of a potent inhibitor of 15‐prostaglandin dehydrogenase.
Year:
2023
Year:
2023
Year:
2022
Collaborators (2)
Joseph M. Ready
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Barbara Triggs-Raine
Professor
University of Manitoba
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