Stephen Hughes

Lab Chief

National Cancer Institute

United States

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Stephen Hughes serves as Lab Chief at the National Cancer Institute in the United States. His research focuses on antiviral therapies, particularly in the areas of HIV-1 integrase inhibitors and the impact of HPV oncogenes in cervical cancer. Recent publications highlight his work on drug-resistant HIV-1 mutants and genomic integration of SARS-CoV-2 sequences. Through his contributions, he aims to enhance understanding and treatment options for viral infections.

Articles (11)

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2025

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2024

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2023

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2021

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2021

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2021

Collaborators (2)

Zhi-Ming Zheng

National Institutes of Health

UNITED STATES

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Anthony Flamier

Assistant professor

CHU Sainte-Justine

CANADA

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Stephen Hughes

Research Interests

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Articles (11)

Comparative Analyses of Antiviral Potencies of Second-Generation Integrase Strand Transfer Inhibitors (INSTIs) and the Developmental Compound 4d Against a Panel of Integrase Quadruple Mutants

HPV oncogenes expressed from only one of multiple integrated HPV DNA copies drive clonal cell expansion in cervical cancer

N-Substituted Bicyclic Carbamoyl Pyridones: Integrase Strand Transfer Inhibitors that Potently Inhibit Drug-Resistant HIV-1 Integrase Mutants

Potent dual block to HIV-1 infection using lentiviral vectors expressing fusion inhibitor peptide mC46- and Vif-resistant APOBEC3G.

LINE1-Mediated Reverse Transcription and Genomic Integration of SARS-CoV-2 mRNA Detected in Virus-Infected but Not in Viral mRNA-Transfected Cells

A Practical Approach to Bicyclic Carbamoyl Pyridones with Application to the Synthesis of HIV-1 Integrase Strand Transfer Inhibitors

INSTIs and NNRTIs Potently Inhibit HIV-1 Polypurine Tract Mutants in a Single Round Infection Assay

Reply to Briggs et al.: Genomic integration and expression of SARS-CoV-2 sequences can explain prolonged or recurrent viral RNA detection

Publisher Correction: Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Response to Parry et al.: Strong evidence for genomic integration of SARS-CoV-2 sequences and expression in patient tissues

Structural basis for the inhibition of HTLV-1 integration inferred from cryo-EM deltaretroviral intasome structures

Collaborators (2)

Zhi-Ming Zheng

Anthony Flamier

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