Stephen M. Black

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Professor & Chair

Florida International University

United States

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About

Stephen M. Black is a Professor & Chair at Florida International University, United States. His research focuses on metabolic pathways in pulmonary hypertension and lung injury, as evidenced by his recent work on glutaminolysis, RNA methylation, and mitochondrial dynamics. He has contributed significantly to understanding cardiopulmonary interactions and the molecular mechanisms underlying these conditions.

Recent Grants

Grant: Close

Metabolic Reprogramming and Pulmonary Vascular Disease in Congenital Heart Disease

Open Date: 2020-08-10

Close Date: 2025-07-31

Grant: Close

PKG Signaling and Sepsis Induced ALI

Open Date: 2018-08-01

Close Date: 2023-05-31

Grant: Close

Genetics, Epigenetics, and Post-translational Modifications and the Development of Ventilator Induced Lung Injury (VILI)

Open Date: 2018-02-05

Close Date: 2023-01-31

Grant: Close

Perinatal NO signaling in congenital heart disease

Open Date: 2017-04-01

Close Date: 2022-02-28

Grant: Close

Endothelial Barrier Protection and Repair in Acute Lung Injury

Open Date: 2011-07-10

Close Date: 2017-12-31

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Collaborators (11)

Kim Tieu

Professor

Florida International University

UNITED STATES

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Saurabh Aggarwal

Assistant Professor

The University of Alabama

UNITED STATES

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Qing Lu

Associate Professor

Florida International University

UNITED STATES

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Ting Wang

UNITED STATES

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John Choy

Catholic University of America

UNITED STATES

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Manivannan Yegambaram

Florida International University

UNITED STATES

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Hoshang Unwalla

Florida International University

UNITED STATES

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Timothy Marlowe

Chief Scientific Officer

Reacnostics GmbH

UNITED STATES

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Maria Clara Franco

Associate Professor (tenured)

Florida International University

UNITED STATES

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Irfan Rahman

University of Rochester Medical Center

UNITED STATES

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David Marciano

Assistant Professor

Florida International University

UNITED STATES

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Stephen M. Black

Research Interests

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About

Recent Grants

Articles (30)

Ventilator-induced Lung Injury Associated With Endothelial Cell Mitochondrial Fission

Restoration of pp60<SUP>Src</SUP> Re-Establishes Electron Transport Chain Complex I Activity in Pulmonary Hypertensive Endothelial Cells

Mitochondrial fission produces a Warburg effect via the oxidative inhibition of prolyl hydroxylase domain-2

Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling

Metabolomic Evidence of Biological Overlap with Heart Failure with Preserved Ejection Fraction in a Subset of Pulmonary Arterial Hypertension

c-Myc promotes metabolic reprogramming in pulmonary hypertension via the stimulation of glutaminolysis and the reductive tricarboxylic acid cycle

Endotoxin-induced m6A RNA methylation landscape in lung endothelial cells: role of METTL3 in regulating inflammation and injury during acute lung injury

Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation

Comprehensive physicochemical, biophysical, and in vitro characterization of lung surfactant SP-A peptidomimetics

Drp1-associated genes implicated in sepsis survival

Altered Host microRNAomics in HIV Infections: Therapeutic Potentials and Limitations

Inflammatory lung injury is associated with endothelial cell mitochondrial fission and requires the nitration of RhoA and cytoskeletal remodeling

Novel Mechanism of Cyclic Nucleotide Crosstalk Mediated by PKG-dependent Proteasomal Degradation of the Hsp90 Client Protein Phosphodiesterase 3A

Free Radical–Associated Gene Signature Predicts Survival in Sepsis Patients

Mitochondrial network dynamics in pulmonary disease: Bridging the gap between inflammation, oxidative stress, and bioenergetics

Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation

Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III

SARS-CoV-2 spike protein induces IL-18-mediated cardiopulmonary inflammation via reduced mitophagy

Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission.

Metabolic reprogramming, oxidative stress, and pulmonary hypertension

Circadian-Coupled Genes Expression and Regulation in HIV-Associated Chronic Obstructive Pulmonary Disease (COPD) and Lung Comorbidities

SOX17 Deficiency Mediates Pulmonary Hypertension At the Crossroads of Sex, Metabolism, and Genetics

Exploring m6A-RNA methylation as a potential therapeutic strategy for acute lung injury and acute respiratory distress syndrome

The Novel Lysosomal Autophagy Inhibitor (ROC-325) Ameliorates Experimental Pulmonary Hypertension

PTK2-associated gene signature could predict the prognosis of IPF

Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells

APE1/Ref-1 is a Novel Redox-Sensitive Element of Lipopolysaccharide-Induced NF-κB-dependent Inflammatory Response in a Cellular Model of Acute Lung Injury

Loss of SOX18/CLAUDIN5 disrupts the pulmonary endothelial barrier in ventilator-induced lung injury.

Abstract 13625: Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases

Abstract 14973: Upregulated Sphingosine-1-Phosphate Receptor 3 Disrupts Endothelial Cell Barrier and Mitochondrial Network Dynamics

Collaborators (11)

Kim Tieu

Saurabh Aggarwal

Qing Lu

Ting Wang

John Choy

Manivannan Yegambaram

Hoshang Unwalla

Timothy Marlowe

Maria Clara Franco

Irfan Rahman

David Marciano

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