Stephen Tapscott

Fred Hutchinson Cancer Research Center

United States

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Articles (14)

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2025

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2024

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2024

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2022

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2022

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2022

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2022

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2022

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2021

Collaborators (5)

Lucas Sullivan

Affiliate Assistant Professor

University of Washington

UNITED STATES

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Jessica de Greef

Assistant Professor

Leiden University Medical Center

NETHERLANDS

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Silvère M van der Maarel

Leiden University Medical Center

NETHERLANDS

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Iris Marieke Willemsen

Leiden University Medical Center

NETHERLANDS

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Susan Kloet

Assistant Professor - Head, Leiden Genome Technology Center

Leiden University Medical Center

NETHERLANDS

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Stephen Tapscott

Research Interests

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Articles (14)

DUX4 activates common and context-specific intergenic transcripts and isoforms

Facioscapulohumeral Dystrophy: Molecular Basis and Therapeutic Opportunities

DUX4-induced HSATII transcription causes KDM2A/B–PRC1 nuclear foci and impairs DNA damage response

DUX4 expression in cancer induces a metastable early embryonic totipotent program

Human DUX4 and porcine DUXC activate similar early embryonic programs in pig muscle cells: implications for preclinical models of FSHD

Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs

Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells

Elevated plasma complement components in facioscapulohumeral dystrophy

Canine DUXC: implications for DUX4 retrotransposition and preclinical models of FSHD

Chromosome 10q-linked FSHD identifies DUX4 as principal disease gene

Facioscapulohumeral dystrophy transcriptome signatures correlate with different stages of disease and are marked by different MRI biomarkers

Publisher Correction: Unchecked oxidative stress in skeletal muscle prevents outgrowth of disseminated tumour cells (Nature Cell Biology, (2022), 24, 4, (538-553), 10.1038/s41556-022-00881-4)

Systemic delivery of a DUX4-targeting antisense oligonucleotide to treat facioscapulohumeral muscular dystrophy

Collaborators (5)

Lucas Sullivan

Jessica de Greef

Silvère M van der Maarel

Iris Marieke Willemsen

Susan Kloet

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