Stina Syvänen

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Associate Professor

Uppsala University

Sweden

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About

Stina Syvänen is an Associate Professor at Uppsala Universitet in Sweden. Her research focuses on innovative therapeutic approaches for Alzheimer's disease and advanced imaging techniques, including the development of bispecific antibodies and PET imaging of neuroinflammation. Recent publications underscore her commitment to understanding and improving the clearance and efficacy of Alzheimer’s treatments through novel antibody design and imaging methodologies.

Recent Grants

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PET imaging of soluble amyloid-β in Alzheimer’s disease

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Articles (18)

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2025

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2025

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2022

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2021

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2021

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2020

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2020

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2020

Collaborators (7)

Erik T. Jansson

Assistant professor

Uppsala University

SWEDEN

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Paul O'Callaghan

Uppsala University

SWEDEN

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Enrica Cerilli

Uppsala University

SWEDEN

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Jonas Eriksson

Uppsala University

SWEDEN

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Dag Sehlin

Associate professor

Uppsala Universitet Medicinska fakulteten

SWEDEN

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Xiaotian Fang

Yale University

UNITED STATES

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Greta Hultqvist

Senior Lecturer/ docent

Uppsala University

SWEDEN

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Stina Syvänen

Research Interests

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About

Recent Grants

Articles (18)

Bispecific brain-penetrant antibodies for treatment of Alzheimer’s disease

PET imaging of TREM2 in amyloid-beta induced neuroinflammation

Somatostatin therapy, neprilysin activation, and amyloid beta reduction: A novel approach for Alzheimer's treatment

Comprehensive Approach for Sequential MALDI-MSI Analysis of Lipids, N-Glycans, and Peptides in Fresh-Frozen Rodent Brain Tissues

Reducing neonatal Fc receptor binding enhances clearance and brain-to-blood ratio of TfR-delivered bispecific amyloid-β antibody

Indium-111 radiolabelling of a brain-penetrant Aβ antibody for SPECT imaging

Antibody engagement with amyloid‐beta does not inhibit [11C]PiB binding for PET imaging

Single domain antibody-scFv conjugate targeting amyloid β and TfR penetrates the blood–brain barrier and interacts with amyloid β

Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

PET Imaging in Preclinical Anti-Aβ Drug Development

Wide-Ranging Effects on the Brain Proteome in a Transgenic Mouse Model of Alzheimer’s Disease Following Treatment with a Brain-Targeting Somatostatin Peptide

11C-PIB and 124I-antibody PET provide differing estimates of brain amyloid-beta after therapeutic intervention

Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

Pinpointing Brain TREM2 Levels in Two Mouse Models of Alzheimer's Disease.

Enhanced neprilysin-mediated degradation of hippocampal Aβ42 with a somatostatin peptide that enters the brain.

Fluorine-18-Labeled Antibody Ligands for PET Imaging of Amyloid-β in Brain

SPECT imaging of distribution and retention of a brain-penetrating bispecific amyloid-β antibody in a mouse model of Alzheimer’s disease

Brain delivery of biologics using a cross-species reactive transferrin receptor 1 VNAR shuttle.

Collaborators (7)

Erik T. Jansson

Paul O'Callaghan

Enrica Cerilli

Jonas Eriksson

Dag Sehlin

Xiaotian Fang

Greta Hultqvist

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