Sung Hee Choi

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Clinical Assistant Professor,

Case Western Reserve University

United States

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About

Sung Hee Choi is a Clinical Assistant Professor at Case Western Reserve University. Based in the United States, Dr. Choi's research focuses on the interplay between immune responses and cancer biology, notably the roles of Piezo1 in T-cell activation and the implications of TGF-β pathways in tumor progression and immunity.

Recent Grants

Grant: Close

c-Myc regulation by TGF-beta signaling as a therapeutic target in Osteosarcoma

Open Date: 2023-12-01

Close Date: 2025-11-30

Grant: Close

Cryoablation-induced STING Activation in Sarcoma Immunotherapy

Open Date: 2020-07-01

Close Date: 2021-06-30

Articles (10)

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2025

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2024

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2023

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2023

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2023

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2022

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2022

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2022

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2021

Year:

2020

Collaborators (2)

James J. Driscoll

Case Western Reserve University

UNITED STATES

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Alex Huang

Professor

Case Western Reserve University School of Medicine

UNITED STATES

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Sung Hee Choi

Research Interests

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Contact this professor

About

Recent Grants

Articles (10)

Piezo1 restrains proinflammatory response but is essential in T-cell–mediated immunopathology

Oral transforming growth factor‐beta receptor 1 inhibitor vactosertib promotes osteosarcoma regression by targeting tumor proliferation and enhancing anti‐tumor immunity

Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation

Piezo1 facilitates optimal T cell activation during tumor challenge

Piezo1 facilitates optimal T cell activation during tumor challenge.

Ectopic Tumor VCAM-1 Expression in Cancer Metastasis and Therapy Resistance

Overexpression of VEGF in the MOPC 315 Plasmacytoma Induces Tumor Immunity in Mice

Smad4-deficient T cells promote colitis-associated colon cancer <i>via</i> an IFN-γ-dependent suppression of 15-hydroxyprostaglandin dehydrogenase.

Novel therapies emerging in oncology to target the TGF-β pathway

Loss of p27Kip1 leads to expansion of CD4+ effector memory T cells and accelerates colitis-associated colon cancer in mice with a T cell lineage restricted deletion of Smad4.

Collaborators (2)

James J. Driscoll

Alex Huang

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