Taichi Mitsui
Chief Researcher
JapanResearch Interests
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About
Taichi Mitsui is the Chief Researcher at Api Co., Ltd. in Japan. His research focuses on the anti-allergic properties of Australian bee pollen, as well as its biochemical activities related to catechol-O-methyltransferase and monoamine oxidase B. Additionally, he has investigated the protective effects of blueberry honey from Canada against cytotoxicity in human buccal mucosal cells and conducted NMR and HPLC profiling of bee pollen products from various countries.
Articles (5)
Year:
2025
Bee pollen is an apicultural product collected by honeybees from flower stamens and used as a functional food worldwide. In the present study, we aim to elucidate the functions of Australian bee pollen. Australian bee pollen extracts and their main components were tested for catechol-O-methyltransferase (COMT) and monoamine oxidase B (MAOB) inhibitory activities. These enzymes are key neurotransmitters involved in Parkinson's disease and depression. Myricetin (5), tricetin (6), and luteolin (7) exhibited high COMT inhibitory activities (half maximal inhibitory concentration [IC50] = 23.3, 13.8, and 47.4 µM, respectively). In contrast, 5, 7, and annulatin (8) exhibited MAOB inhibitory activities (IC50 = 89.7, 32.8, and 153 µM, respectively). Quantitative analysis via high-performance liquid chromatography revealed that 5 was abundant in Australian bee pollen extracts. Our findings suggest that 5 contributes to the COMT and MAOB inhibitory activities of Australian bee pollen.
Year:
2024
Year:
2023
Year:
2022
Year:
2022
Collaborators (3)
Peng Lu
Assistant Professor
University of Tokyo
Shigenori Kumazawa
Shizuoka University
Koji Nagata
Professor
University of Tokyo
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