Takehiko Kobayashi

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University of Tokyo

Japan

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About

Takehiko Kobayashi is a Professor at The University of Tokyo, Japan. His research areas include the regulation of ribosomal RNA gene copy number, transcription, and nucleolus organization in eukaryotes, as well as the stability of ribosomal DNA during DNA repair processes. His recent articles examine the impact of transcription near DNA replication forks and the effects of acidic growth conditions on ribosomal RNA gene clusters.

Recent Grants

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Counting system of ribosomal RNA gene copy

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Construction of gene amplification and chromosome vector systems

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Articles (15)

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2025

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2024

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2024

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2024

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2020

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2020

Collaborators (3)

Mariko Sasaki

Associate professor

National Institute of Genetics

JAPAN

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Yukio Mukai

Professor

Nagahama Institute of Bio-Science and Technology

JAPAN

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Christoph Engel

Prof. for Structural Biochemistry (Tenure Track)

University of Regensburg

GERMANY

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Takehiko Kobayashi

Research Interests

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About

Recent Grants

Articles (15)

Transcription near arrested DNA replication forks triggers ribosomal DNA copy number changes

Acidic growth conditions stabilize the ribosomal <scp>RNA</scp> gene cluster and extend lifespan through noncoding transcription repression

Comparative analysis and classification of highly divergent mouse rDNA units based on their intergenic spacer (IGS) variability

Replication fork blocking deficiency leads to a reduction of rDNA copy number in budding yeast

Spt4 promotes cellular senescence by activating non-coding RNA transcription in ribosomal RNA gene clusters.

Regulation of ribosomal RNA gene copy number, transcription and nucleolus organization in eukaryotes

Regulatory processes that maintain or alter ribosomal DNA stability during the repair of programmed DNA double-strand breaks.

RPS12 and UBC4 Are Related to Senescence Signal Production in the Ribosomal RNA Gene Cluster

Secreted acid phosphatases maintain replicative lifespan via inositol polyphosphate metabolism in budding yeast

Changed life course upon defective replication of ribosomal RNA genes

The human ribosomal DNA array is composed of highly homogenized tandem clusters

Evaluation of repair activity by quantification of ribonucleotides in the genome

The S-Phase Cyclin Clb5 Promotes rRNA Gene (rDNA) Stability by Maintaining Replication Initiation Efficiency in rDNA

Age-Dependent Ribosomal DNA Variations in Mice

The CCR4-NOT Complex Maintains Stability and Transcription of rRNA Genes by Repressing Antisense Transcripts

Collaborators (3)

Mariko Sasaki

Yukio Mukai

Christoph Engel

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