Tao Che

Assistant Professor

Washington University in St. Louis

United States

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Articles (15)

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2024

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2024

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2024

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2022

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2021

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2021

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2021

Collaborators (5)

William Wetsel

Associate Research Professor

Duke University Medical Center

UNITED STATES

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Casey J. Krusemark

Purdue University

UNITED STATES

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James P. Phelan

GlaxoSmithKline

UNITED STATES

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Marta Filizola

Dean

Icahn School of Medicine at Mount Sinai

UNITED STATES

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Christian Billesbølle

University of California, San Francisco

UNITED STATES

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Tao Che

Research Interests

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Articles (15)

Limitations and potential of κOR biased agonists for pain and itch management

GPCR‐G protein selectivity revealed by structural pharmacology

Liver ACOX1 regulates levels of circulating lipids that promote metabolic health through adipose remodeling

Ligand efficacy modulates conformational dynamics of the µ-opioid receptor

Capturing receptor states with glue

Direct Selection of DNA-Encoded Libraries for Biased Agonists of GPCRs on Live Cells

Insights into distinct signaling profiles of the µOR activated by diverse agonists

Structure-based design of bitopic ligands for the µ-opioid receptor

Docking for EP4R antagonists active against inflammatory pain

Bespoke library docking for 5-HT2A receptor agonists with antidepressant activity

Structure determination of inactive-state GPCRs with a universal nanobody

Spotlight on Nociceptin/Orphanin FQ Receptor in the Treatment of Pain

A promising chemical series of positive allosteric modulators of the μ-opioid receptor that enhance the antinociceptive efficacy of opioids but not their adverse effects

Advances in the Treatment of Chronic Pain by Targeting GPCRs

Predicted Mode of Binding to and Allosteric Modulation of the μ-Opioid Receptor by Kratom’s Alkaloids with Reported Antinociception In Vivo

Collaborators (5)

William Wetsel

Casey J. Krusemark

James P. Phelan

Marta Filizola

Christian Billesbølle

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