Thomas M. Durcan

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McGill University

Canada

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Building a screenable human 3D neuromuscular junction model for neuromuscular disorders

Open Date: 2022-05-02

Close Date: 2024-05-01

Articles (17)

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Collaborators (13)

Ludger Schöls

Section head

Eberhard Karls Universität Tübingen

GERMANY

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jack antel

McGill University

CANADA

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Christiane Zweier

SWITZERLAND

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Jonathan Krett

Clinical Assistant Professor & Staff Neurologist

University of Alberta Hospital

CANADA

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Luisa Pimentel

McGill University

CANADA

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Maria Theresa Norn

Aarhus University

DENMARK

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Christopher Moraes

Associate Professor

McGill University

CANADA

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Sheng-Jia Lin

Assistant Professor

Utah Tech University

UNITED STATES

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Jean-François Trempe

McGill University

CANADA

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Stefano Stifani

Professor

McGill University

CANADA

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Kalle Gehring

CANADA

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Benoit Coulombe

Institut de recherches cliniques de Montréal

CANADA

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Steve Bourgault

CANADA

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Thomas M. Durcan

Research Interests

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Recent Grants

Articles (17)

Evaluation of Additive Neuroprotective Effect of Combination Therapy for Parkinson’s Disease Using In Vitro Models

Microfabricated dynamic brain organoid cocultures to assess the effects of surface geometry on assembloid formation

Cover Image, Volume 72, Issue 6

Early nuclear phenotypes and reactive transformation in human iPSC‐derived astrocytes from ALS patients with SOD1 mutations

Loss of symmetric cell division of apical neural progenitors drives DENND5A-related developmental and epileptic encephalopathy

Towards a Treatment for Leukodystrophy Using Cell-Based Interception and Precision Medicine

Modeling Parkinson's disease pathology in human dopaminergic neurons by sequential exposure to α-synuclein fibrils and proinflammatory cytokines.

Archetypes of Open Science Partnerships: connecting aims and means in open biomedical research collaborations

An Inducible Luminescent System to Explore Parkinson’s Disease-Associated Genes

CelltypeR: A flow cytometry pipeline to characterize single cells from brain organoids.

Transcriptional Dysregulation and Impaired Neuronal Activity in FMR1 Knock-Out and Fragile X Patients’ iPSC-Derived Models

α-Synuclein Preformed Fibrils Bind to β-Neurexins and Impair β-Neurexin-Mediated Presynaptic Organization

An Optimized Workflow to Generate and Characterize iPSC-Derived Motor Neuron (MN) Spheroids

Selective localization of Mfn2 near PINK1 enables its preferential ubiquitination by Parkin on mitochondria

TDP-43 dysregulation and neuromuscular junction disruption in amyotrophic lateral sclerosis

Rapid Generation of Ventral Spinal Cord-like Astrocytes from Human iPSCs for Modeling Non-Cell Autonomous Mechanisms of Lower Motor Neuron Disease

Generation of human midbrain organoids from induced pluripotent stem cells

Collaborators (13)

Ludger Schöls

jack antel

Christiane Zweier

Jonathan Krett

Luisa Pimentel

Maria Theresa Norn

Christopher Moraes

Sheng-Jia Lin

Jean-François Trempe

Stefano Stifani

Kalle Gehring

Benoit Coulombe

Steve Bourgault

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