Tilman Brummer

University of Freiburg

Germany

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Articles (19)

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2025

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Collaborators (12)

Tiago Maié

Rheinisch Westfälische Technische Hochschule Aachen RWTH Aachen Fakultät für Mathematik Informatik und Naturwissenschaft

GERMANY

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C. Benedikt Westphalen

GERMANY

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Peter Horak

Deputy Head of Department

UniversitätsKlinikum Heidelberg

GERMANY

GERMANY

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Chris Meisinger

GERMANY

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Ralph M. Fritsch

SWITZERLAND

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Joern Dengjel

Professor for Biochemistry and Cell Biology

University of Fribourg

SWITZERLAND

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Tilman Brummer

Research Interests

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Articles (19)

Saturation mutational scanning uncovers druggability of all FGFR kinase point mutations

DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring

The mTOR pathway controls phosphorylation of BRAF at T401

Enzyme Is the Name—Adapter Is the Game

MOST wanted: navigating the MAPK-OIS-SASP-tumor microenvironment axis in primary pediatric low-grade glioma and preclinical models.

Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines.

Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer.

Association of RNF43 Genetic Alterations With BRAFV600E and MSIhigh in Colorectal Cancer

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease

Mast cell deficiency prevents BCR::ABL1 induced splenomegaly and cytokine elevation in a CML mouse model

BRAF <sup>Δβ3-αC</sup> in-frame deletion mutants differ in their dimerization propensity, HSP90 dependence, and druggability

Case of a Patient With Pancreatic Cancer With Sporadic Microsatellite Instability Associated With a <i>BRAF</i> Fusion Achieving Excellent Response to Immunotherapy

MAPK inhibitor sensitivity scores predict sensitivity driven by the immune infiltration in pediatric low-grade gliomas.

MDM2 Inhibition Enhances Immune Checkpoint Inhibitor Efficacy by Increasing IL15 and MHC Class II Production

The role of the MDM2/p53 axis in anti-tumor immune responses.

Analysis of RAS and drug induced homo- and heterodimerization of RAF and KSR1 proteins in living cells using split Nanoluc luciferase

Charting co-mutation patterns associated with actionable drivers in intrahepatic cholangiocarcinoma

Charting co-mutation patterns associated with actionable drivers in intrahepatic cholangiocarcinoma

RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells.

Collaborators (12)

Tiago Maié

C. Benedikt Westphalen

Peter Horak

F.-Nora Vögtle

Thomas Reinheckel

Robert Zeiser

Augusto Andrade

Claudia Ball

Michèle Simon

Chris Meisinger

Ralph M. Fritsch

Joern Dengjel

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