Tim Somervaille

Cancer Research UK Manchester Institute

United Kingdom

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Articles (11)

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2025

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2025

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2023

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2022

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2022

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2021

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2021

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2020

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2020

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2020

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2020

Collaborators (3)

ROSA MARIA AYALA DIAZ

Full Professor

Universidad Complutense de Madrid

SPAIN

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Fabrizio Simeoni

Cancer Research UK Manchester Institute

UNITED KINGDOM

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Daniel Wiseman

The University of Manchester

UNITED KINGDOM

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Tim Somervaille

Research Interests

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Articles (11)

Addition of navitoclax to ruxolitinib for patients with myelofibrosis with progression or suboptimal response

Multi-omic analysis of chronic myelomonocytic leukemia monocytes reveals metabolic and immune dysregulation leading to altered macrophage polarization

Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO

Addition of Navitoclax to Ongoing Ruxolitinib Therapy for Patients With Myelofibrosis With Progression or Suboptimal Response: Phase II Safety and Efficacy

Pharmacological inhibition of LSD1 triggers myeloid differentiation by targeting GSE1 oncogenic functions in AML

Blast cells surviving acute myeloid leukemia induction therapy are in cycle with a signature of FOXM1 activity.

Enhancer recruitment of a RUNX1, HDAC1 and TLE3 co-repressor complex by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia

Targeted nanopore sequencing for the identification of ABCB1 promoter translocations in cancer.

A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia

Pre-clinical activity of combined LSD1 and mTORC1 inhibition in MLL-translocated acute myeloid leukaemia

Dynamic induction of drug resistance through a stress-responsive enhancer in acute myeloid leukemia

Collaborators (3)

ROSA MARIA AYALA DIAZ

Fabrizio Simeoni

Daniel Wiseman

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