Tohru Dairi

Professor

Hokkaido University

Japan

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Professor Tohru Dairi is a faculty member at Hokkaido University, Japan. His research focuses on microbial natural products, specifically investigating the biosynthesis of various peptides and inhibitors, including peptaibols and lactacystin. Recent publications highlight his work on understanding enzyme specificities and optimizing biochemical pathways in both eukaryotic and prokaryotic systems.

Articles (16)

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2025

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2025

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2025

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (3)

Takeshi Tsunoda

Project Assistant Professor

Hokkaido University

JAPAN

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Yoshimitsu Hamano

University of Fukui

JAPAN

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Yasuharu Satoh

Hokkaido University

JAPAN

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Tohru Dairi

Research Interests

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Articles (16)

Identification of peptaibols as specific inhibitors of the futalosine pathway

Substrate specificities of two ketosynthases in eukaryotic microalgal and prokaryotic marine bacterial DHA synthases

Biosynthesis of lactacystin as a proteasome inhibitor

Identification of a new oligomycin derivative as a specific inhibitor of the alternative peptidoglycan biosynthetic pathway

Peptide Epimerase Responsible for d-Amino Acid Introduction in Poly-γ-glutamic Acid Biosynthesis

Optimization of tyrosol-producing pathway with tyrosine decarboxylase and tyramine oxidase in high-tyrosine-producing Escherichia coli

Peptide epimerase-dehydratase complex responsible for biosynthesis of the linaridin class ribosomal peptides

Structure of lasso peptide epimerase MslH reveals metal-dependent acid/base catalytic mechanism

Studies on biosynthetic enzymes leading to structural and functional diversity of microbial natural products

N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry

First direct evidence for direct cell-membrane penetrations of polycationic homopoly(amino acid)s produced by bacteria

Biosynthetic Gene Cluster of Linaridin Peptides Contains Epimerase Gene

Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes

Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes

Discovery of an alternative pathway of peptidoglycan biosynthesis: A new target for pathway specific inhibitors

Identification of pulvomycin as an inhibitor of the futalosine pathway

Collaborators (3)

Takeshi Tsunoda

Yoshimitsu Hamano

Yasuharu Satoh

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