Tohru Kimura

Professor

Kitasato University

Japan

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Tohru Kimura is a Professor at Kitasato University, Japan. His research focuses on stem cell biology, epigenetics, and tissue aging, as evidenced by his recent publications on topics such as human intestinal organoids, chromatin remodeling, and the genetic variation impacting DNA methylation. Professor Kimura's work aims to uncover mechanisms that govern cell differentiation and maintenance, contributing to the understanding of both health and disease.

Articles (12)

Year:

2024

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

Year:

2021

Collaborators (6)

YOICHI SEKITA

Associate Professor

JAPAN

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Anna K. Naumova

CANADA

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Toshinobu Nakamura

Professor

Nagahama Institute of Bio-Science and Technology

JAPAN

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Shin Kobayashi

National Institute of Advanced Industrial Science and Technology

JAPAN

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Teruko Taketo

Professor

McGill University

CANADA

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Kei-ichiro Ishiguro

Professor

Kumamoto University

JAPAN

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Tohru Kimura

Research Interests

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Articles (12)

Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells

Switching defective/sucrose non‐fermenting chromatin remodeling complex coordinates meiotic gene activation via promoter remodeling and Meiosin activation in female germline

Spatiotemporal changes of tissue glycans depending on localization in cardiac aging

Stem cell challenges and opportunities.

Genetic variation in the Y chromosome and sex-biased DNA methylation in somatic cells in the mouse.

Epigenome editing reveals core DNA methylation for imprinting control in the <i>Dlk1-Dio3</i> imprinted domain

Drug metabolic activity is a critical cell-intrinsic determinant for selection of hepatocytes during long-term culture

Puromycin-based purification of cells with high expression of the cytochrome P450 CYP3A4 gene from a patient with drug-induced liver injury (DILI)

SWI/SNF chromatin remodeling complex is required for initiation of sex-dependent differentiation in mouse germline

AKT signaling is associated with epigenetic reprogramming via the upregulation of TET and its cofactor, alpha-ketoglutarate during iPSC generation.

Ammonia-based enrichment and long-term propagation of zone I hepatocyte-like cells

A RUNX-CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes.

Collaborators (6)

YOICHI SEKITA

Anna K. Naumova

Toshinobu Nakamura

Shin Kobayashi

Teruko Taketo

Kei-ichiro Ishiguro

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