Tomasz Borowski

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Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences

Poland

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Oksygenazy zależne od 2-oksoglutaranu katalizujące atypowe reakcje utleniania - badania nad strukturami oraz mechanizmami enzymatycznymi.

Open Date: 2015-08-01

Close Date: 2019-07-01

Grant: Close

Oksygenazy zależne od 2-oksoglutaranu w biosyntezie alkaloidów o aktywności farmakologicznej - struktury, mechanizmy reakcji i racjonalne przeprojektowywanie enzymów."

Open Date: 2015-05-01

Close Date: 2021-04-01

Articles (16)

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Collaborators (11)

Geeta Upadhyay

Uniformed Services University of the Health Sciences

UNITED STATES

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Lisa M. Berreau

UNITED STATES

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Fahidat Gbadamosi

University of South Carolina

UNITED STATES

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Maciej Szaleniec

Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences

POLAND

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Anna Miłaczewska

Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences

POLAND

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Yuriy Gusev

Georgetown University

UNITED STATES

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Dawid Lupa

Assistant Professor

POLAND

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Miodrag Grbic

University of Western Ontario

CANADA

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Johann Heider

Professor

Philipps-Universität Marburg

GERMANY

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Maksymilian Chruszcz

Professor

Michigan State University

UNITED STATES

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Jozef Korecki

Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences

POLAND

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Tomasz Borowski

Research Interests

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Recent Grants

Articles (16)

Reaction Mechanism Catalyzed by the Dissimilatory Sulfite Reductase – The Role of the Siroheme‐[4FeS4] Cofactor

Bacteria at Work – Experimental and Theoretical Studies Reveal the Catalytic Mechanism of Ectoine Synthase

Experimental and Computational Studies Reveal Novel Interaction of Lymphocytes Antigen 6K to TGF-β Receptor Complex

Molecular Dynamics Simulations for the Michaelis Complex of Ectoine Synthase (EctC)

Structural and functional studies reveal the molecular basis of substrate promiscuity of a glycosyltransferase originating from a major agricultural pest

Inactivation and aggregation of R-specific 1-(4-hydroxyphenyl)-ethanol dehydrogenase from Aromatoleum aromaticum

Lymphocyte antigen 6K signaling to aurora kinase promotes advancement of the cell cycle and the growth of cancer cells, which is inhibited by LY6K-NSC243928 interaction

Development of fluorophore labeled or biotinylated anticancer small molecule NSC243928

Frontispiece: Properties of the Reactants and Their Interactions within and with the Enzyme Binding Cavity Determine Reaction Selectivities. The Case of Fe(II)/2‐Oxoglutarate Dependent Enzymes

Properties of the Reactants and Their Interactions within and with the Enzyme Binding Cavity Determine Reaction Selectivities. The Case of Fe(II)/2‐Oxoglutarate Dependent Enzymes

Mechanistic studies of visible light-induced CO release from a 3-hydroxybenzo[g]quinolone

Enzymatic Δ1-Dehydrogenation of 3-Ketosteroids—Reconciliation of Kinetic Isotope Effects with the Reaction Mechanism

Comparison of different approaches to derive classical bonded force-field parameters for a transition metal cofactor: a case study for non-heme iron site of ectoine synthase

Substitution of histidine 30 by asparagine in manganese superoxide dismutase alters biophysical properties and supports proliferation in a K562 leukemia cell line

A study on the structure, mechanism, and biochemistry of kanamycin B dioxygenase (KanJ)—an enzyme with a broad range of substrates

Enzyme Multifunctionality by Control of Substrate Positioning Within the Catalytic Cycle—A QM/MM Study of Clavaminic Acid Synthase

Collaborators (11)

Geeta Upadhyay

Lisa M. Berreau

Fahidat Gbadamosi

Maciej Szaleniec

Anna Miłaczewska

Yuriy Gusev

Dawid Lupa

Miodrag Grbic

Johann Heider

Maksymilian Chruszcz

Jozef Korecki

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