Tomasz M. Goszczyński

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assistant professor

Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences

Poland

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About

Dr. Tomasz M. Goszczyński is an assistant professor at the Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences. His research focuses on metallacarboranes and their applications in medicinal chemistry, including drug discovery and anticancer potential. Recent publications explore the biological effects of halogen substituents in cobalt bis(dicarbollide) and innovative approaches to cancer therapy using nanoconjugates and immune modulation.

Recent Grants

Grant: Close

Koniugaty metalokarboranów z insuliną - Nowa strategia potęgowania skuteczności biologicznej leków peptydowych

Open Date: 2020-07-02

Close Date: 2024-09-30

Grant: Close

Nowe strategie w terapii nowotworów - bionieorganiczne koniugaty cytostatyków i klasterów boru.

Open Date: 2017-09-14

Close Date: 2020-09-13

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2021

Collaborators (17)

Anna NIKODEM

assistant professor

Politechnika Wroclawska

POLAND

Tomasz M. Goszczyński

Research Interests

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About

Recent Grants

Articles (20)

Unraveling the correlation between biological effects and halogen substituents in cobalt bis(dicarbollide)

From inert to active: Charge-compensated metallacarboranes with high toxicity and anticancer potential

Metallacarboranes: abiotic scaffolds for advanced drug discovery

Metallacarboranes in Medicinal Chemistry: Current Advances and Future Perspectives

Sensing Copper(II) Ions with Hyper Rayleigh Scattering from Gold Nanoparticles

Effect of Ovocystatin on Amyloid β 1-42 Aggregation—In Vitro Studies

Inhibition of MC38 colon cancer growth by multicomponent chemoimmunotherapy with anti-IL-10R antibodies, HES-MTX nanoconjugate, depends on application of IL-12, IL-15 or IL-18 secreting dendritic cell vaccines

Combined therapy with methotrexate nanoconjugate and dendritic cells with downregulated IL-10R expression modulates the tumor microenvironment and enhances the systemic anti-tumor immune response in MC38 murine colon carcinoma

Cobalt bis(dicarbollide) is a DNA-neutral pharmacophore

Evolution of the T4 phage virion is driven by selection pressure from non-bacterial factors

Macro-GH – A clinical entity causing a diagnostic challenge – A case report

Structural Patterns Enhancing the Antibacterial Activity of Metallacarborane-Based Antibiotics

Supramolecular chemistry of anionic boron clusters and its applications in biology

Metallacarborane Derivatives as Innovative Anti-Candida albicans Agents

The Impact of Exosomes/Microvesicles Derived from Myeloid Dendritic Cells Cultured in the Presence of Calcitriol and Tacalcitol on Acute B-Cell Precursor Cell Lines with <i>MLL</i> Fusion Gene

Immunomodulatory potential of anticancer therapy composed of methotrexate nanoconjugate and dendritic cell-based vaccines in murine colon carcinoma

Aromatic Bis[aminomethylidenebis(phosphonic)] Acids Prevent Ovariectomy-Induced Bone Loss and Suppress Osteoclastogenesis in Mice

Metallacarborane Derivatives Effective against Pseudomonas aeruginosa and Yersinia enterocolitica

Age-dependent ataxia and neurodegeneration caused by an αII spectrin mutation with impaired regulation of its calpain sensitivity

Comparison of Antibacterial Mode of Action of Silver Ions and Silver Nanoformulations With Different Physico-Chemical Properties: Experimental and Computational Studies

Collaborators (17)

Anna NIKODEM

Joanna Majewska

Elżbieta Pajtasz-Piasecka

Krzysztof Fink

Anna Nasulewicz-Goldeman

Anna Boguszewska-Czubara

Agnieszka Szczygieł

Anna Kędziora

Bożena Szermer-Olearnik

Krzysztof Pawlik

Wieslaw Swietnicki

Katarzyna Matczyszyn

Izabela Rybicka

Beata Orzechowska

Marek Drab

Joanna Rossowska

Krzysztof Grzymajlo

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