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Tomohiro Tsuchida

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Assistant Professor

University of Tokyo

Japan

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About

Tomohiro Tsuchida is an Associate Professor at Tokyo University of Science in Japan. His research focuses on various aspects of pharmacology and biochemistry, including ligand-selective mechanisms in antibodies, physicochemical properties of pharmaceutical compounds, and the modulation of lipid bilayer fluidity. He has published several articles exploring topics such as antioxidant capacity, molecular interactions, and the stability of ultraviolet filters.

Recent Grants

Grant: Open

液液相分離を標的とした新規アミロイド形成阻害物質の探索

Open Date: 2026-05-01

Close Date: 2027-03-01

Articles (27)

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2023

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2021

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2020

Collaborators (1)

Katsuhiko Minoura

Osaka Medical and Pharmaceutical University

JAPAN

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Tomohiro Tsuchida

Research Interests

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About

Recent Grants

Articles (27)

Kinetic separation of competing pathways in the ascorbate reduction of hydroxocobalamin by singular value decomposition and the dimensionality of the normalized score space

Conformational flexibility governs phosphate-induced solubility enhancement: a comparative study of cimetidine and famotidine by pH-dependent dissolution, NMR titration, DOSY, and DFT analysis

Phospholipid membrane interfaces and metal cations, Ca2+ and Cu2+, modulate insulin amyloid fibrillation

Microenvironmental Modulation of Bromocresol Green upon γ-Cyclodextrin Association Characterized by UV–Vis Spectral Trajectory Analysis

Interfacial sequestration by phospholipid membranes and buffer-dependent dual pathways in heat-induced insulin fibrillation

Interfacial adsorption onto hydrophobic 2,2-diphenyl-1-picrylhydrazyl microaggregates constrains the radical-scavenging activity of capsaicin, curcumin, ferulic acid, and related vanilloid antioxidants

Precise ligand-selective mechanism at the fab domain of a tau-recognizing antibody

Supramolecular synthonic portions in heat-treated indomethacin-carbamazepine mixture: a singular value decomposition approach for Fourier-Transform infrared spectral analysis

Triton X-100 modulates lipid bilayer fluidity in opposing ways at the hydrophilic interface and hydrophobic interior, hindering water transport

Antioxidant capacity of edaravone, quercetin, and myricetin involving probabilistic fluctuations using eosin-Y and eosin-B as fluorescent probes in the ORAC assay

Physicochemical properties of diclofenac regulated by its intermolecular interactions with caffeine evaluated via vector space model, nuclear magnetic resonance, and Fourier-transform infrared analyses

Reactivity of Olanzapine and Tricyclic Antidepressants on the Protective Effects of Trolox on Lipid Peroxidation Evaluated Using Fluorescence Anisotropy, Electron Paramagnetic Resonance Spectrometry, and Thermal Analysis

Equilibrium of monomers, dimers, and polymeric aggregates in the α-aryl-propionic acid-type analgesics naproxen, ketoprofen, and ibuprofen: Comparative study with oxicam-type meloxicam and piroxicam

Stability and Properties of Ultraviolet Filter Avobenzone under Its Diketo/Enol Tautomerization Induced by Molecular Encapsulation with β-Cyclodextrin

Antioxidative Mechanism of Radical Scavenger and Local Anesthetics

Solubility Dynamics and Hydrophobic Interactions of Acidic Analgesics and Basic Anesthetics

Quantification of crystallinity during indomethacin crystalline transformation from α- to γ-polymorphic forms and of the thermodynamic contribution to dissolution in aqueous buffer and solutions of solubilizer

Distinguishing the transitions of fluorescence spectra of tryptophan-134 and 213 in BSA induced by bindings of UV filters, oxybenzone-3, and avobenzone

Comparative study on the effects of the inclusion complexes of non-steroidal anti-inflammatory drugs with 2-hydroxypropyl-β-cyclodextrins on dissociation rates and supersaturation

Quantification of crystallinity during indomethacin crystalline transformation from α- to γ-polymorphic forms and of the thermodynamic contribution to dissolution in aqueous buffer and solutions of solubilizer

Thermodynamic and kinetic analysis of the melting process of S-ketoprofen and lidocaine mixtures

Spring and parachute approach for piroxicam dissolution; its phenomenological model on the thermodynamics of irreversible processes

Nicotinic acetylcholine receptor activation induces BACE1 transcription via the phosphorylation and stabilization of nuclear SP1

Using singular value decomposition to analyze drug/β-cyclodextrin mixtures: insights from X-ray powder diffraction patterns

Structural study of the recognition mechanism of tau antibody Tau2r3 with the key sequence (VQIINK) in tau aggregation

Crystal structure of the human tau PHF core domain VQIINK complexed with the Fab domain of monoclonal antibody Tau2r3

Collaborators (1)

Katsuhiko Minoura

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