Tomohisa Hasunuma

Professor

Kobe University

Japan

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Professor Tomohisa Hasunuma is a faculty member at Kobe University, Japan. His research focuses on metabolic engineering and bioprocesses, specifically in the areas of microbial production, secondary metabolite biosynthesis, and the engineering of酵母菌 for enhanced strain development. His recent publications include significant contributions to the production of anthraquinones and bioactive compounds through innovative microbial strategies.

Articles (20)

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2025

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2022

Collaborators (8)

Naoki Sakai

Japan Synchrotron Radiation Research Institute

JAPAN

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Jun Ishii

Associate Professor

Kobe University

JAPAN

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Ryosuke Munakata

助教 / Assistant Professor

Kyoto University

JAPAN

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Shunsuke Masuo

Assistant Professor

University of Tsukuba

JAPAN

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Lucília Domingues

Associate Professor

University of Minho

PORTUGAL

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Hideo Kawaguchi

Associate Professor

Kobe University

JAPAN

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Shumpei Asamizu

Project Associate Professor

Kobe University

JAPAN

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Jungyeon Kim

University of Illinois at Urbana-Champaign

UNITED STATES

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Tomohisa Hasunuma

Research Interests

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About

Articles (20)

Development of a High Anthraquinone-Producing Escherichia coli Strain Using Malonyl-CoA Supply Pathway Engineering

Harnessing glycerol for secondary metabolite biosynthesis in microorganisms

Identification of Subfamily Specific Residues within Highly Active and Promiscuous Alcohol Dehydrogenases

Difficult-to-culture micro-organisms specifically isolated using the liquid-liquid co-culture method – towards the identification of bacterial species and metabolites supporting their growth

Metabolic engineering and cultivation strategies for efficient production of fucoxanthin and related carotenoids

Introduction of acetyl-phosphate bypass and increased culture temperatures enhanced growth-coupled poly-hydroxybutyrate production in the marine cyanobacterium Synechococcus sp. PCC7002

Metabolic analysis reveals the contribution of mechanosensitive channel MscM to extracellular release of glutamate in glycogen-deficient Synechococcus elongatus

Engineering Saccharomyces cerevisiae for growth on xylose using an oxidative pathway

Engineering of acyl ligase domain in non-ribosomal peptide synthetases to change fatty acid moieties of lipopeptides

De Novo Production of the Bioactive Phenylpropanoid Artepillin C Using Membrane-Bound Prenyltransferase in Komagataella phaffii

Dark accumulation of downstream glycolytic intermediates initiates robust photosynthesis in cyanobacteria

Direct production of 4‐hydroxybenzoic acid from cellulose using cellulase‐displaying Pichia pastoris

Enhanced production of 3,4‐dihydroxybutyrate from xylose by engineered yeast via xylonate re‐assimilation under alkaline condition

Metabolic engineering for 4-aminophenylalanine production from lignocellulosic biomass by recombinant Escherichia coli

Metabolic and Microbial Community Engineering for Four-Carbon Dicarboxylic Acid Production from CO2-Derived Glycogen in the Cyanobacterium Synechocystis sp. PCC6803

Avoiding entry into intracellular protein degradation pathways by signal mutations increases protein secretion in Pichia pastoris

Improvement of cell-tethered cellulase activity in recombinant strains of Saccharomyces cerevisiae

Construction of an l-Tyrosine Chassis in Pichia pastoris Enhances Aromatic Secondary Metabolite Production from Glycerol

Construction of an L-Tyrosine Chassis in Pichia pastoris Enhances Aromatic Secondary Metabolite Production from Glycerol

A streamlined strain engineering workflow with genome-wide screening detects enhanced protein secretion in Komagataella phaffii

Collaborators (8)

Naoki Sakai

Jun Ishii

Ryosuke Munakata

Shunsuke Masuo

Lucília Domingues

Hideo Kawaguchi

Shumpei Asamizu

Jungyeon Kim

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