Toshimasa Itoh

Professor (Drug Design and Medicinal Chemistry)

Showa Pharmaceutical University

Japan

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About

Professor Toshimasa Itoh is a faculty member at Showa Pharmaceutical University in Japan. His research primarily focuses on drug design and medicinal chemistry, as evident from his recent publications on bioconjugation, fluorescence properties of coumarins, and metabolic studies involving chiral compounds. His work contributes significantly to the understanding of covalent modifications and enzyme interactions in drug development.

Articles (11)

Year:

2024

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2023

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

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2021

Collaborators (6)

Takeshi Nakano

Osaka University

JAPAN

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Keiko Yamamoto

Professor

Showa Pharmaceutical University

JAPAN

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Hiroaki Ishida

Senior Assistant Professor

Showa Pharmaceutical University

JAPAN

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Tadashi Mori

Osaka University

JAPAN

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Hiroyuki Kojima

Rockefeller University

UNITED STATES

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Takahiro Yamada

Assistant Professor

Kobe University

JAPAN

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Toshimasa Itoh

Research Interests

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Articles (11)

2-cyanopyridine derivatives enable N-terminal cysteine bioconjugation and peptide bond cleavage of glutathione under aqueous and mild conditions

Synthesis of Triazolo[c]coumarins and Differences in the Fluorescence Properties of Their Isomers

Covalent Modifier Discovery Using Hydrogen/Deuterium Exchange–Mass Spectrometry

Differences in Enantioselective Hydroxylation of 2,2′,3,6-Tetrachlorobiphenyl (CB45) and 2,2′,3,4′,6-Pentachlorobiphenyl (CB91) by Human and Rat CYP2B Subfamilies

Enantioselective metabolism of chiral polychlorinated biphenyl 2,2′,3,4,4′,5′,6-Heptachlorobiphenyl (CB183) by human and rat CYP2B subfamilies

Hydroxylation and dechlorination of 3,3′,4,4′-tetrachlorobiphenyl (CB77) by rat and human CYP1A1s and critical roles of amino acids composing their substrate-binding cavity

Synthesis of Tetrahydrofuro[2,3-d]oxazoles and Oxazoles by Hypervalent Iodine (III)-Promoted [2+2+1] Annulation

Structural insights into the loss-of-function R288H mutant of human PPARγ

HNF4α Is a Covalent Bond-Forming Receptor

Synthesis of a Coumarin-Based PPARγ Fluorescence Probe for Competitive Binding Assay

Construction of 7-diethylaminocoumarins promoted by an electron-withdrawing group

Collaborators (6)

Takeshi Nakano

Keiko Yamamoto

Hiroaki Ishida

Tadashi Mori

Hiroyuki Kojima

Takahiro Yamada

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