Tsuyoshi Hirashima

Principal Investigator/Research Assistant Professor

National University of Singapore (NUS)

Singapore

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Professors in Tissue Engineering

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About

Tsuyoshi Hirashima is a Principal Investigator and Research Assistant Professor at the National University of Singapore. His research focuses on tissue morphogenesis, cellular dynamics, and mechanobiology, as evidenced by his recent publications on topics such as curvature feedback in tissue morphogenesis and collective cell movement. He investigates the regulatory mechanisms of cell adhesion, intercellular viscosity, and signal transduction pathways, contributing to our understanding of tissue organization and dynamics in various biological contexts.

Articles (18)

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2025

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2024

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2024

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2024

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2024

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2023

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2023

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2022

Collaborators (7)

Taichi NODA

Associate Professor

Kumamoto University

JAPAN

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Satoshi Toda

Assistant Professor

Kanazawa University

JAPAN

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Satoko Arakawa

Institute of Science Tokyo

JAPAN

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Chaoyu Fu

National University of Singapore

SINGAPORE

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Chii Jou Chan

Assistant Professor

SINGAPORE

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Michiyuki Matsuda

Professor

Kyoto University

JAPAN

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Katsuya Sakai

Associate Professor

Kanazawa University

JAPAN

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Tsuyoshi Hirashima

Research Interests

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About

Articles (18)

Curvature feedback for repetitive tissue morphogenesis – Bridging algorithmic principles and self-regulatory systems

ERK-mediated curvature feedback regulates branching morphogenesis in lung epithelial tissue

Robust tissue pattern formation by coupling morphogen signal and cell adhesion

Collective sperm movement in mammalian reproductive tracts.

Regulation of intercellular viscosity by E-cadherin-dependent phosphorylation of EGFR in collective cell migration

Collective cell dynamics and luminal fluid flow in the epididymis: A mechanobiological perspective

Apoptotic extracellular vesicle formation via local phosphatidylserine exposure drives efficient cell extrusion

Editorial: Multicellularity: Views from cellular signaling and mechanics

Stretching the limits of extracellular signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation

Tug-of-war via ERK signaling pathway for tissue organization – ERK activation to force generation

Interplay between Mechanochemical Patterning and Glassy Dynamics in Cellular Monolayers

A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration

A visualization system for erectile vascular dynamics

Tissue hydraulics in reproduction

C-type Natriuretic Peptide–induced PKA Activation Promotes Endochondral Bone Formation in Hypertrophic Chondrocytes

Functional visualization of NK cell-mediated killing of metastatic single tumor cells

Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development

Mechanical Feedback Control for Multicellular Tissue Size Maintenance: A Minireview

Collaborators (7)

Taichi NODA

Satoshi Toda

Satoko Arakawa

Chaoyu Fu

Chii Jou Chan

Michiyuki Matsuda

Katsuya Sakai

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