Ulrike Koehl

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Professor and Director, Institute for Clinical Immunology

University Hospital Leipzig

Germany

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About

Ulrike Koehl is a Professor and Director at the Institute for Clinical Immunology, University Hospital Leipzig. Her research focuses on advanced approaches in immunotherapy, specifically T cell immunotherapies utilizing CRISPR technology and chimeric antigen receptors. Additionally, she explores the implications of regulatory frameworks for personalized medicine in the context of precision oncology. Her recent publications highlight innovative techniques and clinical applications in gene therapy and T cell activation.

Recent Grants

Grant: Open

Central European Advanced Therapy and Immunotherapy Centre (CREATIC)

Open Date: 2023-01-01

Close Date: 2029-01-01

Grant: Open

Eine First-in-Human Klinische Phase-I Studie mit ROR2- spezifischen CAR-T Zellen, die den Transkriptionsfaktor Batf3 zur Steigerung von Funktion und Persistenz überexprimieren, in Patienten mit ROR2+ Tumoren (Multiples Myelom, Klarzelliges Nierenkarzinom)

Open Date: 2023-01-01

Close Date: 2028-01-01

Grant: Close

Arming natural killer cells for immuno-therapy against acute myeloid leukemia (NK fit against AML)

Open Date: 2021-01-01

Close Date: 2023-01-01

Grant: Close

Accelerating Development and Improving Access to CAR and TCR-engineered T cell therapy (T2EVOLVE)

Open Date: 2021-01-01

Close Date: 2025-01-01

Grant: Close

Artificial Intelligence-driven, Decentralized Production for Advanced Therapies in the Hospital (AIDPATH)

Open Date: 2021-01-01

Close Date: 2025-01-01

Articles (13)

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2025

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2024

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2023

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2023

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2023

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2023

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2023

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2023

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2023

Collaborators (3)

Thomas Grunwald

Head of Group "Preclinical Studies"

Fraunhofer Institute for Cell Therapy and Immunology

GERMANY

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Johanna Olweus

Professor

University of Oslo

NORWAY

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Zoltan Ivics

Head of Department

Fraunhofer Institute for Cell Therapy and Immunology

GERMANY

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Ulrike Koehl

Research Interests

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About

Recent Grants

Articles (13)

Next-generation T cell immunotherapies engineered with CRISPR base and prime editing: challenges and opportunities

Effective use of anti-CD19 chimeric antigen receptor T cells in a case of treatment-resistant granulomatosis with polyangiitis

Development of KoRV-pseudotyped lentiviral vectors for efficient gene transfer into freshly isolated immune cells

New regulatory thinking is needed for AI-based personalised drug and cell therapies in precision oncology

Correction to: Efficient generation of gene-modified human natural killer cells via alpharetroviral vectors.

Non-viral vectors for chimeric antigen receptor immunotherapy

Current strategies of cell and gene therapy for solid tumors: results of the joint international ESMO and CTIWP-EBMT survey.

A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation.

Accelerating development of engineered T cell therapies in the EU: current regulatory framework for studying multiple product versions and T2EVOLVE recommendations

CAR T cells for treating autoimmune diseases.

CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma

Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality

Lipid nanoparticles outperform electroporation in mRNA-based CAR T cell engineering.

Collaborators (3)

Thomas Grunwald

Johanna Olweus

Zoltan Ivics

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