Vicente Pelechano

Vicente Pelechano’s Research Group at Karolinska Institutet is offering a postdoctoral scholarship in computational and structural RNA biology. The project sits at the intersection of RNA biology, computational biology, and genome-wide method development, with a strong emphasis on how RNA sequence and structure shape gene regulation and cellular phenotypes. The successful candidate will work on understanding how variation in untranslated regions, especially alternative 3′ UTR isoforms and natural or engineered UTR sequence changes, alters RNA structure and influences mRNA fate. The research combines structure prediction and modelling with genome-wide experimental datasets in complementary human and yeast systems, aiming to build structure-aware predictive models of RNA regulation. The position is embedded in an interdisciplinary and international research environment within the Department of Microbiology, Tumor and Cell Biology (MTC) at Karolinska Institutet. The lab is based at SciLifeLab on the Karolinska Institutet campus, giving access to advanced instrumentation and core facilities. The group’s work bridges experimental and computational approaches to fundamental biological questions with medical relevance. The project offers the chance to carry out original research in RNA structure, post-transcriptional regulation, and computational analysis while developing both experimental and computational expertise. The role also involves scientific communication, teamwork, and interaction with researchers from diverse backgrounds in a highly collaborative setting.