Vinay Puduvalli

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Professor and Chair

The University of Texas MD Anderson Cancer Center

United States

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About

Vinay Puduvalli is a Professor and Chair at The University of Texas M. D. Anderson Cancer Center in the United States. His research primarily focuses on gliomas, particularly in relation to IDH mutations, tumor microenvironment, and innovative therapeutic strategies. Recent publications highlight significant advances in understanding astrocytoma survival mechanisms, glioblastoma cell sensitization to chemotherapy, and integrated molecular diagnostics for gliomas.

Recent Grants

Grant: Close

Characterization of Onalespib, A novel long acting Hsp90 inhibitor, as a chemo and radiosensitizer in Adults with Newly Diagnosed Glioblastoma

Open Date: 2019-01-01

Close Date: 2023-12-31

Grant: Close

Patient Oriented Research Program in Neuro-oncology

Open Date: 2012-04-13

Close Date: 2016-03-31

Grant: Close

Efficacy and toxicity of TRAIL against gliomas

Open Date: 2006-01-05

Close Date: 2011-12-31

Grant: Close

Correlative trial of fenretinide against Glioblastomas

Open Date: 2002-09-01

Close Date: 2005-08-31

Articles (16)

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2024

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2021

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2021

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2021

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2020

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2020

Collaborators (8)

Pratibha Sharma

Assistant Professor

The University of Texas MD Anderson Cancer Center

UNITED STATES

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Jing Li

Professor

UNITED STATES

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Hideho Okada

University of California, San Francisco

UNITED STATES

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J. Bryan Iorgulescu

The University of Texas MD Anderson Cancer Center

UNITED STATES

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Abdullah F. Alasmari

SAUDI ARABIA

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Yu Shyr

Professor and Chair

Vanderbilt University Medical Center

UNITED STATES

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Robert Wesolowski

Assistant Professor

Ohio State University

UNITED STATES

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Ashley Aaroe

The University of Texas MD Anderson Cancer Center

UNITED STATES

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Vinay Puduvalli

Research Interests

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About

Recent Grants

Articles (16)

Protocol for real-time assessment of mitochondrial and glycolytic ATP production in patient-derived glioma stem-like cells

A first-in-human phase 1 study of BXQ-350, a first-in-class sphingolipid metabolism regulator, in patients with advanced/recurrent solid tumors or high-grade gliomas

Epichaperome Inhibition by PU-H71-Mediated Targeting of HSP90 Sensitizes Glioblastoma Cells to Alkylator-Induced DNA Damage

MGMT promoter methylation and survival following chemotherapy for WHO grade 4 IDH-mutant astrocytoma

Multidisciplinary Management of Isocitrate Dehydrogenase–Mutated Gliomas in a Contemporary Molecularly Defined Era

Final report of the phase II NEXT/CNS-GCT-4 trial: GemPOx followed by marrow-ablative chemotherapy for recurrent intracranial germ cell tumors

Multicenter Phase II Trial of the PARP Inhibitor Olaparib in Recurrent IDH1- and IDH2-mutant Glioma

Tumor microenvironment in glioblastoma: Current and emerging concepts.

Triethylammonium salt of a synthesized dicoumarol: Structural insight and human anti-glioblastoma activities

An expedited strategy for accurate and timely integrated molecular diagnosis of gliomas

Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the nicotinamide adenine dinucleotide (NAD) salvage pathway, to target glioma heterogeneity through mitochondrial oxidative stress

Demystifying demethylator sensitivity in gliomas: role for TERT and DNMT1

Management of gliomas in patients with Lynch syndrome

Results of a phase I trial to assess the safety of macitentan in combination with temozolomide for the treatment of recurrent glioblastoma

Phase I trial of intracerebral convection-enhanced delivery of carboplatin for treatment of recurrent high-grade gliomas

A Bayesian adaptive randomized phase II multicenter trial of bevacizumab with or without vorinostat in adults with recurrent glioblastoma

Collaborators (8)

Pratibha Sharma

Jing Li

Hideho Okada

J. Bryan Iorgulescu

Abdullah F. Alasmari

Yu Shyr

Robert Wesolowski

Ashley Aaroe

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