Vincent Giguère

Professor

McGill University Faculty of Medicine

Canada

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Vincent Giguère is a Professor at McGill University Faculty of Medicine in Canada. His research focuses on molecular mechanisms of transcriptional regulation, particularly in relation to energy metabolism, cancer biology, and the role of nuclear receptors. Recent publications include studies on ERRα's function in endurance and myofiber transformation, as well as the involvement of mTOR in transcriptional regulation within prostate cancer cells.

Articles (14)

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2024

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2024

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2023

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2023

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2023

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2023

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2022

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2022

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2022

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2022

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2022

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2022

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2021

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2021

Collaborators (2)

Maya Saleh

Full Professor of Immunology

Institut national de la recherche scientifique

CANADA

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Charlotte Scholtes

INSERM

FRANCE

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Vincent Giguère

Research Interests

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Articles (14)

Identification of a chromatin-bound ERRα interactome network in mouse liver

Canonical and Nuclear mTOR Specify Distinct Transcriptional Programs in Androgen-Dependent Prostate Cancer Cells

Hierarchical Phosphorylation of HOXB13 by mTOR Dictates Its Activity and Oncogenic Function in Prostate Cancer

Transcription initiation by the ERRs: no ligand but two activation pathways

ERRα fosters running endurance by driving myofiber aerobic transformation and fuel efficiency

Hepatocyte FBXW7-dependent activity of nutrient-sensing nuclear receptors controls systemic energy homeostasis and NASH progression in male mice

Chronicle of a discovery: the retinoic acid receptor

Retinoic acid receptors at 35: molecular convergence of vitamin A and steroid hormone action

Transcriptional control of energy metabolism by nuclear receptors

Rapid immunoprecipitation mass spectrometry of endogenous protein (RIME) to identify chromatin-interactome in prostate cancer cells

Insulin action and resistance are dependent on a GSK3β-FBXW7-ERRα transcriptional axis

The mTOR chromatin-bound interactome in prostate cancer.

Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways.

Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis.

Collaborators (2)

Maya Saleh

Charlotte Scholtes

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