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Vincent Luca

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PI & Assistant Member

H Lee Moffitt Cancer Center and Research Institute

United States

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Deconstructing the molecular mechanisms of Notch receptor-ligand selectivity

Open Date: 2017-06-27

Close Date: 2020-05-31

Articles (9)

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2024

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2024

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2024

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2023

Collaborators (8)

Ana Teixeira

Associate Professor

Karolinska Institutet

SWEDEN

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Björn Högberg

Professor at Karolinska Institutet

Karolinska Institutet

SWEDEN

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Eric Lau

Associate Professor

Knight Cancer Institute, Oregon Health and Science University

UNITED STATES

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Daiki Karigane

Stanford University

UNITED STATES

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Kathleen Loomes

Professor

Children's Hospital of Philadelphia

UNITED STATES

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Lay Teng Ang

Assistant Professor

Stanford University

UNITED STATES

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David Sprinzak

Tel Aviv University

ISRAEL

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Björn Reinius

Assistant Professor

Karolinska Institutet

SWEDEN

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Vincent Luca

Research Interests

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Recent Grants

Articles (9)

Soluble and multivalent Jag1 DNA origami nanopatterns activate Notch without pulling force

Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.

Functional characterization of 2,832 JAG1 variants supports reclassification for Alagille syndrome and improves guidance for clinical variant interpretation

Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer looping

Structural basis for mouse LAG3 interactions with the MHC class II molecule I-A<sup>b</sup>

Structure of the planar cell polarity cadherins Fat4 and Dachsous1

Fucosylation of HLA-DRB1 regulates CD4<sup>+</sup> T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy.

Affinity-matured DLL4 ligands as broad-spectrum modulators of Notch signaling

New tricks for an old pathway: emerging Notch-based biotechnologies and therapeutics

Collaborators (8)

Ana Teixeira

Björn Högberg

Eric Lau

Daiki Karigane

Kathleen Loomes

Lay Teng Ang

David Sprinzak

Björn Reinius

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