Walter Becker

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Medizinische Fakultät der RWTH Aachen

Germany

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Recent Grants

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Rational development of selective Inhibitors of the protein kinase DYRK1B

Open Date: 2019-01-01

Close Date:

Grant: Close

Development of a specific inhibitor of the protein kinase DYRK1A

Open Date: 2010-01-01

Close Date: 2014-01-01

Articles (9)

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2024

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2024

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2024

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2024

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2022

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2022

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2021

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2021

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2020

Collaborators (5)

Moustafa Gabr

Assistant Professor

Weill Cornell Medicine

UNITED STATES

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Conrad Kunick

GERMANY

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Matthias Engel

Saarland University

GERMANY

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Steffen Koschmieder

RWTH Aachen University

GERMANY

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Stefan Düsterhöft

GERMANY

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Walter Becker

Research Interests

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Contact this professor

Recent Grants

Articles (9)

Functional characterization of two DYRK1B variants causative of AOMS3

Elevated expression levels of the protein kinase DYRK1B induce mesenchymal features in A549 lung cancer cells

Differential regulation of expression of the protein kinases DYRK1A and DYRK1B in cancer cells.

Discovery and Functional Characterization of a Potent, Selective, and Metabolically Stable PROTAC of the Protein Kinases DYRK1A and DYRK1B.

Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects

Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.

Discovery of Hydroxybenzothiazole Urea Compounds as Multitargeted Agents Suppressing Major Cytotoxic Mechanisms in Neurodegenerative Diseases.

The Unfolded Protein Response Is a Major Driver of LCN2 Expression in BCR–ABL- and JAK2V617F-Positive MPN

How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition—The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine

Collaborators (5)

Moustafa Gabr

Conrad Kunick

Matthias Engel

Steffen Koschmieder

Stefan Düsterhöft

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