wenshe Liu

Has grant

Harry E. Bovay, Jr. Endowed Chair and Professor in Chemistry

Texas A&M University

United States

Research Interests

Explore related searches

Professors in United States Professors in Immunology Immunology professors in United States

Contact this professor

Get a free first email built on one of their papers, ready for you to edit and send yourself.

About

Wenshe Liu is the Harry E. Bovay, Jr. Endowed Chair and Professor in Chemistry at Texas A&M University, USA. His research areas include genetically encoded lysine chemistry, therapeutic innovations, and the development of chemical tools for protein analysis. Recent articles authored by Professor Liu focus on the engineering of fluorescent probes, protein editing techniques, and the investigation of epigenetic targets for therapeutic applications.

Recent Grants

Grant: Close

Development of fluorogenic and chemiluminogenic main protease substrates for cellular and in vivo imaging of SARS-CoV-2

Open Date: 2022-05-01

Close Date: 2024-02-29

Grant: Open

Use of the Noncanonical Amino Acid Mutagenesis Technique in Combination with Other Approaches to Study Functions of Posttranslational Lysine Modifications in Proteins

Open Date: 2022-04-01

Close Date: 2027-03-31

Grant: Close

Targeting the ENL YEATS domain for the development of anti-leukemia agents

Open Date: 2021-12-03

Close Date: 2023-11-30

Grant: Close

STTR Phase I: Discovery and Development of Macrocyclic Peptide Inhibitors of SARS-COV-2 Spike Protein for the Treatment of COVID-19

Open Date: 2021-07-01

Close Date: 2022-07-31

Grant: Close

Develop General Methods for the Synthesis of Proteins with Posttranslational Lysine Modifications

Open Date: 2019-01-15

Close Date: 2022-11-30

Articles (25)

Year:

2025

Year:

2025

Year:

2025

Year:

2025

Year:

2025

Year:

2025

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2024

Year:

2023

Year:

2023

Year:

2023

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Year:

2022

Collaborators (4)

Xin Yan

Assistant Professor

Texas A&M University

UNITED STATES

View details

Tatiana Kutateladze

Professor/Associate Professor/Assistant Professor

University of Colorado School of Medicine

UNITED STATES

View details

Shiqing Xu

Assistant Professor

Texas A&M University

UNITED STATES

View details

Carol Fierke

Provost and Executive Vice President for Academic Affairs, and Professor of Biochemistry

Brandeis University

UNITED STATES

View details

ApplyKite TwinLearns as you apply

Make your next move.

Prepare your application

Review drafts before you send them.

wenshe Liu

Research Interests

Explore related searches

Contact this professor

About

Recent Grants

Articles (25)

Advancing Genetically Encoded Lysine (GEK) Chemistry: From Precision Modulation to Therapeutic Innovation

A Simple, Quick, and Scalable Route to Fluorogenic Ubiquitin and Ubiquitin-Like Protein Substrates for Assessing Activities of Deubiquitinases and Ubiquitin-Like Protein-Specific Proteases

Development of Chemical Tools for the Human YEATS Domain

Editing proteins inside a cell

2-Cyanopyrimidine-Containing Molecules for N-Terminal Selective Cyclization of Phage-Displayed Peptides

Epigenetic reader chromodomain as a potential therapeutic target

Leveraging a Phage-Encoded Noncanonical Amino Acid: A Novel Pathway to Potent and Selective Epigenetic Reader Protein Inhibitors

BRD4354 Is a Potent Covalent Inhibitor against the SARS-CoV-2 Main Protease

Directed Evolution of Candidatus Methanomethylophilus alvus Pyrrolysyl-tRNA Synthetase for the Genetic Incorporation of Two Different Noncanonical Amino Acids in One Protein

Diversification of Phage-Displayed Peptide Libraries with Noncanonical Amino Acid Mutagenesis and Chemical Modification

Prioritization of Eleven-Nineteen-Leukemia Inhibitors as Orally Available Drug Candidates for Acute Myeloid Leukemia

Computational Model-Assisted Development of a Nonenzymatic Fluorescent Glucose-Sensing Assay

A Novel Y-Shaped, S–O–N–O–S-Bridged Cross-Link between Three Residues C22, C44, and K61 Is Frequently Observed in the SARS-CoV-2 Main Protease

An amber-encoding helper phage for more efficient phage display of noncanonical amino acids

A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease

Phage‐assisted, active site‐directed ligand evolution of a potent and selective histone deacetylase 8 inhibitor

Novel Regioselective Approach to Cyclize Phage-Displayed Peptides in Combination with Epitope-Directed Selection to Identify a Potent Neutralizing Macrocyclic Peptide for SARS-CoV-2

Evolutionary and Structural Insights about Potential SARS-CoV-2 Evasion of Nirmatrelvir

A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals

A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells**

Cover Picture: A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells (Angew. Chem. Int. Ed. 10/2022)

Titelbild: A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells (Angew. Chem. 10/2022)

A Reversible Chemogenetic Switch for Chimeric Antigen Receptor T Cells**

Drug Repurposing for the SARS‐CoV‐2 Papain‐Like Protease

Front Cover: MPI8 is Potent against SARS‐CoV‐2 by Inhibiting Dually and Selectively the SARS‐CoV‐2 Main Protease and the Host Cathepsin L (ChemMedChem 1/2022)

Collaborators (4)

Xin Yan

Tatiana Kutateladze

Shiqing Xu

Carol Fierke

Make your next move.