William Copeland

Chief and Senior Investigator

National Institute of Environmental Health Sciences

United States

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William Copeland is a Chief and Senior Investigator at the National Institute of Environmental Health Sciences in the United States. His research focuses on mitochondrial DNA repair pathways, the structural analysis of DNA binding proteins, and the role of various enzymes in mitochondrial function. Recent publications highlight his work on coronavirus ribonucleases and advancements in cryo-electron microscopy techniques for evaluating mitochondrial components.

Articles (11)

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2025

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2024

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2024

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2023

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2022

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2022

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2022

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2022

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2021

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2021

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2021

Collaborators (4)

Jason Williams

National Institute of Environmental Health Sciences

UNITED STATES

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Sara N. Andres

CANADA

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Ali Naini

Professor

Columbia University

UNITED STATES

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Meredith Frazier

College of Charleston

UNITED STATES

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William Copeland

Research Interests

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About

Articles (11)

DNA repair pathways in the mitochondria

Structures of the mitochondrial single-stranded DNA binding protein with DNA and DNA polymerase γ

Coordinated DNA polymerization by Polγ and the region of LonP1 regulated proteolysis

Structure-specific roles for PolG2–DNA complexes in maintenance and replication of mitochondrial DNA

Method for the structural analysis of Twinkle mitochondrial DNA helicase by cryo-EM

Recent insights into the structure and function of coronavirus ribonucleases

Automated systematic evaluation of cryo-EM specimens with SmartScope

Structural insight and characterization of human Twinkle helicase in mitochondrial disease

Activation of the SARS-CoV-2 NSP14 3'-5' exoribonuclease by NSP10 and response to antiviral inhibitors

Whole-Exome Sequencing Identifies a Novel POLG Frameshift Variant in an Adult Patient Presenting with Progressive External Ophthalmoplegia and Mitochondrial DNA Depletion.

Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces

Collaborators (4)

Jason Williams

Sara N. Andres

Ali Naini

Meredith Frazier

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