William Hancock

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Pennsylvania State University

United States

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Recent Grants

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Single-molecule imaging of lignocellulose deconstruction by SCATTIRSTORM microscopy

Open Date: 2018-09-01

Close Date: 2021-08-31

Grant: Close

Multimotor mechanisms in microtubule-based transport

Open Date: 2017-01-01

Close Date: 2021-01-01

Grant: Close

Molecular mechanism of kinesin motiliy

Open Date: 2016-01-01

Close Date: 2020-01-01

Grant: Close

Bridging Understanding of Motor-Cargo Transport from Artificial to Cellular Systems

Open Date: 2016-01-01

Close Date: 2020-01-01

Grant: Close

Kinesin and +TIP-based microtubule steering

Open Date: 2012-09-21

Close Date: 2016-08-31

Articles (16)

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2025

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2021

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2021

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2021

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2020

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2020

Collaborators (3)

Lauren McCormick

University of Texas Southwestern Medical Center

UNITED STATES

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Keith Mickolajczyk

Assistant Professor

Rutgers New Jersey Medical School

UNITED STATES

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Melissa Rolls

Professor

Pennsylvania State University

UNITED STATES

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William Hancock

Research Interests

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Recent Grants

Articles (16)

Motor clustering enhances kinesin-driven vesicle transport

Cargo adaptor identity controls the mechanism and kinetics of dynein activation

Measuring PETase enzyme kinetics by single-molecule microscopy

Single-molecule tracking reveals dual front door/back door inhibition of Cel7A cellulase by its product cellobiose

Interface-acting nucleotide controls polymerization dynamics at microtubule plus- and minus-ends

Interface-acting nucleotide controls polymerization dynamics at microtubule plus- and minus-ends

Simulations suggest robust microtubule attachment of kinesin and dynein in antagonistic pairs

KIF1A is kinetically tuned to be a superengaging motor under hindering loads

Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport

Measurements and simulations of microtubule growth imply strong longitudinal interactions and reveal a role for GDP on the elongating end

Trim9 and Klp61F promote polymerization of new dendritic microtubules along parallel microtubules

Measuring microtubule binding kinetics of membrane-bound kinesin motors using supported lipid bilayers

Nanoscale dynamics of cellulose digestion by the cellobiohydrolase TrCel7A

Integrated multi-wavelength microscope combining TIRFM and IRM modalities for imaging cellulases and other processive enzymes

What is the correct stoichiometry of Kv2.1:Kv6.4 heteromers?

A kinetic dissection of the fast and superprocessive kinesin-3 KIF1A reveals a predominant one-head-bound state during its chemomechanical cycle

Collaborators (3)

Lauren McCormick

Keith Mickolajczyk

Melissa Rolls

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