William Jacobs

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Albert Einstein College of Medicine

United States

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About

William Jacobs is a Professor at the Albert Einstein College of Medicine in the United States. His research focuses on Mycobacterium tuberculosis and Mycobacterium leprae, specifically their virulence, drug interactions, and mechanisms of pathogenesis. Recent publications include studies on the ESX-5 secretion locus, the effects of vitamin C on drug efficacy, and advancements in gene transfer methodologies for mycobacterial research.

Recent Grants

Grant: Close

Shortening Tuberculosis Chemotherapies using N-acetylcysteine

Open Date: 2018-06-15

Close Date: 2020-05-31

Grant: Close

Generation of a Complete Set of Precise Null Bar-Coded Deletion Mutants of Mycobacterium tuberculosis

Open Date: 2017-09-14

Close Date: 2022-08-31

Grant: Close

Attenuated HSV Vaccines That Induce Protective Mucosal Antibodies

Open Date: 2016-03-01

Close Date: 2020-02-28

Grant: Close

Reporter Phages for Diagnosis of Drug-Resistant TB in HIV High-Burden Populations

Open Date: 2013-08-15

Close Date: 2015-03-16

Grant: Close

Drugs targeting persistent Mycobacterium Tuberculosis

Open Date: 2013-04-01

Close Date: 2018-03-31

Articles (17)

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The University of Texas at El Paso Department of Biological Sciences

UNITED STATES

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William Jacobs

Research Interests

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About

Recent Grants

Articles (17)

Loss of the ESX-5 secretion locus in Mycobacterium tuberculosis reshapes the mycomembrane and enhances ESX-1 substrate secretion

Vitamin C potentiates the killing of Mycobacterium tuberculosis by bedaquiline through metabolic disruption

Loss of PPE71-esxX-esxY-PPE38 drives adaptive transcriptional responses and hypervirulence of Mycobacterium tuberculosis Lineage 2

Mycobacteriophage-mediated gene transfer enables in vitro drug screening and in vivo tracking of Mycobacterium leprae

The SapM phosphatase can arrest phagosome maturation in an ESX-1 independent manner in Mycobacterium tuberculosis and BCG

Boosting Immunogenicity of a Recombinant <i>Mycobacterium smegmatis</i> Strain via Zinc-Dependent Ribosomal Proteins

Propionate prevents loss of the PDIM virulence lipid in Mycobacterium tuberculosis

Mycobacterium smegmatis: The Vanguard of Mycobacterial Research

Capturing Structural Variants of Herpes Simplex Virus Genome in Full Length by Oxford Nanopore Sequencing

The Promises and Limitations of N -Acetylcysteine as a Potentiator of First-Line and Second-Line Tuberculosis Drugs

Sterilization by Adaptive Immunity of a Conditionally Persistent Mutant of Mycobacterium tuberculosis

Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

BCG-Prime and boost with Esx-5 secretion system deletion mutant leads to better protection against clinical strains of Mycobacterium tuberculosis

Nanoluciferase Reporter Mycobacteriophage for Sensitive and Rapid Detection of Mycobacterium tuberculosis Drug Susceptibility

HVEM signaling promotes protective antibody-dependent cellular cytotoxicity (ADCC) vaccine responses to herpes simplex viruses

Characterization of large deletion mutants of Mycobacterium tuberculosis selected for isoniazid resistance.

Collaborators (6)

Michael Berney

Faramarz Valafar

Miriam Braunstein

Rohit K Jangra

Yasu Morita

Sangeeta Tiwari

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