William Peter Sheffield

Professor

McMaster University

Canada

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William Peter Sheffield is a Professor at McMaster University in Canada. His research focuses on the specificity and functionality of protease inhibitors, including investigations into plasma kallikrein and alpha-1 antitrypsin variants. Additionally, he explores advancements in blood transfusion practices and the overarching implications of serine proteinase inhibitors in medical applications.

Articles (10)

Year:

2025

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2025

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2025

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2024

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2024

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2024

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2024

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2023

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2023

Year:

2023

Collaborators (6)

James Irving

Principal Research Fellow (Assoc. Prof.)

University College London

UNITED KINGDOM

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Margarethe Geiger

Associate Professor

Medical University of Vienna

AUSTRIA

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Marie-Christine BOUTON

INSERM U1148

FRANCE

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Grant McFadden

Professor and Director of B-CIVV

Arizona State University

UNITED STATES

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Ulrich J. Sachs

GERMANY

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David Lomas

University College London

UNITED KINGDOM

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William Peter Sheffield

Research Interests

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About

Articles (10)

Enhancement of plasma kallikrein specificity of antitrypsin variants identified by phage display and partial reversion

Expression and purification of a broad-spectrum human protease inhibitor in Pichia pastoris

Substitution of reactive centre loop residues from C1 esterase inhibitor increases the inhibitory specificity of alpha-1 antitrypsin for plasma kallikrein

Prolonging the circulatory half-life of C1 esterase inhibitor via albumin fusion

Extension of the circulatory half-life of recombinant ecallantide via albumin fusion without loss of anti-kallikrein activity

Human Fc gamma receptor IIIA blockade inhibits platelet destruction in a humanized murine model of ITP

Prehospital Freeze-Dried Plasma in Trauma: A Critical Review

The under‐appreciated world of the serpin family of serine proteinase inhibitors

A positive blood culture is associated with a lower haemoglobin increment in hospitalized patients after red blood cell transfusion

Correction of haemorrhagic shock-associated coagulopathy and impaired haemostasis by plasma, prothrombin complex concentrates or an activated protein C-targeted DNA aptamer in mice()

Collaborators (6)

James Irving

Margarethe Geiger

Marie-Christine BOUTON

Grant McFadden

Ulrich J. Sachs

David Lomas

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