X. Long Zheng

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Professor and chair

University of Kansas Medical Center

United States

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About

X. Long Zheng is a Professor and Chair at the University of Kansas Medical Center in the United States. His research focuses on thrombotic thrombocytopenic purpura, including the management guidelines and underlying genetic factors. He has published extensively on topics such as ADAMTS13 activity, platelet transfusion reactions, and the effects of neutrophil extracellular traps in various medical conditions.

Recent Grants

Grant: Open

Pathogenesis of Thrombotic Microangiopathy

Open Date: 2023-08-01

Close Date: 2027-07-01

Grant: Close

Mechanism underlying cofactor-dependent proteolysis of von Willebrand Factor

Open Date: 2022-02-01

Close Date: 2026-01-31

Grant: Close

Novel Therapeutics for Acquired Thrombotic Thrombocytopenic Purpura

Open Date: 2019-04-01

Close Date: 2023-03-31

Grant: Close

Pathogenesis of Thrombotic Microangiopathy

Open Date: 2015-09-14

Close Date: 2019-03-31

Grant: Close

Novel Therapeutics for Acquired Thrombotic Thrombocytopenic Purpura

Open Date: 2013-06-01

Close Date: 2017-05-31

Articles (21)

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UNITED STATES

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Noritaka Yada

Assistant Proffesor

Nara Medical University

JAPAN

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Xinyang Zhao

associate professor

University of Kansas Medical Center

UNITED STATES

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Zhan Ye

UNITED STATES

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X. Long Zheng

Research Interests

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About

Recent Grants

Articles (21)

2025 focused update of the 2020 ISTH guidelines for management of thrombotic thrombocytopenic purpura

Modeling ANKRD26 5′-UTR mutation-related thrombocytopenia

A mutant complement factor H (W1183R) enhances proteolytic cleavage of von Willebrand factor by ADAMTS-13 under shear

Arginine Methylation by PRMT1 Affects ADAMTS13 Secretion and Enzymatic Activity

ABO incompatibility and component irradiation are independently associated with platelet transfusion reaction rate

Preventative and therapeutic effects of a novel humanized anti-GPIbα Fab fragment in a murine model of thrombotic thrombocytopenic purpura

Genetic Variants Contribute to Modulation of Renal Function in Patients with Immune Thrombotic Thrombocytopenic Purpura

Targeting neutrophil extracellular trap accumulation under flow in patients with immune-mediated thrombotic thrombocytopenic purpura

ADAMTS13 or Caplacizumab Reduces the Accumulation of Neutrophil Extracellular Traps and Thrombus in Whole Blood of COVID-19 Patients under Flow

Clinical Utility of Recently Food and Drug Administration-Approved IntelliSep Test (Sepsis Biomarker) for Early Diagnosis of Sepsis: Comparison with Other Biomarkers

Mechanisms of Inhibition of Human Monoclonal Antibodies in Immune Thrombotic Thrombocytopenic Purpura

Longitudinal Assessment of Plasma Syndecan-1 Predicts 60-Day Mortality in Patients with COVID-19

A novel mechanism underlying allosteric regulation of ADAMTS-13 revealed by hydrogen−deuterium exchange plus mass spectrometry

Dynamic Assessment of Plasma von Willebrand Factor and ADAMTS13 Predicts Mortality in Hospitalized Patients with SARS-CoV-2 Infection

Race, rituximab, and relapse in TTP

Animal models for thrombotic thrombocytopenic purpura: a narrative review

Changes in Plasma Levels of ADAMTS13 and von Willebrand Factor in Patients Undergoing Elective Joint Arthroplasty

ADAMTS13 conformations and mechanism of inhibition in immune thrombotic thrombocytopenic purpura

ADAMTS13 protease or lack of von Willebrand factor protects irradiation and melanoma‐induced thrombotic microangiopathy in zebrafish

A Simple, Robust, and Cost-effective Method for Genotyping Small-scale Mutations

Protein Arginine Methyltransferase 1 in the Generation of Immune Megakaryocytes: A Perspective Review

Collaborators (8)

Zechen Chong

Michael Evans

Milind Phadnis

Elizabeth Staley

Raj Kasthuri

Noritaka Yada

Xinyang Zhao

Zhan Ye

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