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Xinwen Wang

Assistant Professor

Northeast Ohio Medical University

United States

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Research Interests

Biochemistry

70%

Pharmacology

50%

Metabolic Biology

50%

Fatty Liver

50%

Pharmacometrics

20%

Covid-19

20%

Bioanalytical Chemistry

20%

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Recent Grants

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Pre-K Award

Open Date: 2018-03-01

Close Date: 2020-03-01

Articles13

Hepatic FOXA3 overexpression prevents Western diet–induced obesity and MASH through TGR5

Article Link

Year:

2024

Differential Bioactivation Profiles of Different GS-441524 Prodrugs in Cell and Mouse Models: ProTide Prodrugs with High Cell Permeability and Susceptibility to Cathepsin A Are More Efficient in Delivering Antiviral Active Metabolites to the Lung

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Year:

2024

Transplacental methadone exposure and risk of Neonatal Opioid Withdrawal Syndrome

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Year:

2023

Genome-Wide Association Study for the Genetic Determinants of Thiopurine Methyltransferase Protein Expression in Human Livers and Racial Differences

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Year:

2023

Identification of regulatory variants of carboxylesterase 1 (CES1): A proof‐of‐concept study for the application of the Allele‐Specific Protein Expression (ASPE) assay in identifying cis‐acting regulatory genetic polymorphisms

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Year:

2023

Microbial products linked to steatohepatitis are reduced by deletion of nuclear hormone receptor SHP in mice

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Year:

2023

Altered serotonin metabolism in Takeda G protein-coupled receptor 5 knockout mice protects against diet-induced hepatic fibrosis

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Year:

2022

Bile acid conjugation deficiency causes hypercholanemia, hyperphagia, islet dysfunction, and gut dysbiosis in mice

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Year:

2022

Tissue‐ and cell‐expression of druggable host proteins provide insights into repurposing drugs for COVID‐19

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Year:

2022

Integrating pharmacogenomics into clinical trials of hearing disorders

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Year:

2022

Effect of CES1 genetic variation on enalapril steady‐state pharmacokinetics and pharmacodynamics in healthy subjects

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Year:

2021

Tissue-Specific Proteomics Analysis of Anti-COVID-19 Nucleoside and Nucleotide Prodrug-Activating Enzymes Provides Insights into the Optimization of Prodrug Design and Pharmacotherapy Strategy

Article Link

Year:

2021

Comparative Proteomics Analysis of Human Liver Microsomes and S9 Fractions

Article Link

Year:

2020

Collaborators9

Samuel Trammell

Københavns Universitet

DENMARK

Jianxin Bao

Duke University

UNITED STATES

Audrey H. Wu

University of Michigan Health System

UNITED STATES

Hao-Jie Zhu

University of Michigan

UNITED STATES

Hazel A. Barton

University of Akron

UNITED STATES

Yanqiao Zhang

Northeast Ohio Medical University

UNITED STATES

Mirjavid Aghayev

Northeast Ohio Medical University

UNITED STATES

Jessica Ferrell

Assistant Professor

Northeast Ohio Medical University

UNITED STATES

Trisha Grevengoed

Københavns Universitet

DENMARK

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